Hyperinsulinemia in pre- and post-pubertal children born small for gestational age

Hormone Research
N PotauA Carrascosa

Abstract

Reduced fetal growth is a potential risk factor for development of metabolic abnormalities in later life. The relationship between low birthweight and impaired glucose tolerance, type 2 diabetes and insulin resistance in adulthood has been well documented. Assuming that fetal undernutrition is associated with insulin resistance in middle age, we elected to study whether this process may already be present in young adults and adolescents born small for gestational age (SGA). Children born in Vall d'Hebron Hospital Infantil, Barcelona, between 1986 and 1989 and between 1978 and 1983 with birthweights below the third centile for the local standard values, were invited to participate in the present study. Of those, 51 (22 girls and 29 boys) were pre-pubertal with 9.4 +/- 0.2 years of age and 49 (29 girls and 20 boys ) were post-pubertal, with 17.3 +/- 0.3 years of age. All patients underwent a standard, 2-hour oral glucose tolerance test. Insulin and glucose responses were compared with our previously published data in control children with normal birthweight. The insulin response at 30 min after glucose load was significantly higher (p < 0.001) in pre- and post-pubertal girls and boys formerly SGA than in controls. In addition, th...Continue Reading

Citations

Oct 7, 2008·Advances in Therapy·Heike JungStenvert L S Drop
Aug 2, 2003·Current Opinion in Pediatrics·Tandy Aye, Lynne L Levitsky
Oct 29, 2004·Journal of Cognitive Neuroscience·M J TaylorR J Itier
Apr 18, 2007·BMC Evolutionary Biology·Milind G Watve, Chittaranjan S Yajnik
May 12, 2007·The Review of Diabetic Studies : RDS·Caterina Geremia, Stefano Cianfarani
Aug 30, 2005·Advances in Pediatrics·Orit Pinhas-Hamiel, Phil Zeitler
Sep 6, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Caterina Geremia, Stefano Cianfarani
Nov 4, 2016·Nature Reviews. Endocrinology·Veronica MericqAnita Hokken-Koelega

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