Hyperinsulinemia is associated with increased production rate of intestinal apolipoprotein B-48-containing lipoproteins in humans

Arteriosclerosis, Thrombosis, and Vascular Biology
Hélène DuezG F Lewis

Abstract

Whereas postprandial hyperlipidemia is a well-described feature of insulin-resistant states and type 2 diabetes, no previous studies have examined intestinal lipoprotein production rates (PRs) in relation to hyperinsulinemia or insulin resistance in humans. Apolipoprotein B-48 (apoB-48)-containing lipoprotein metabolism was examined in the steady-state fed condition with a 15-hour primed constant infusion of [D3]-l-leucine in 14 nondiabetic men with a broad range of body mass index (BMI) and insulin sensitivity. To examine the relationship between indices of insulin resistance and intestinal lipoprotein PR data were analyzed in 2 ways: by correlation and by comparing apoB-48 PRs in those whose fasting plasma insulin concentrations were above or below the median for the 14 subjects studied (60 pmol/L). ApoB-48 PR was significantly higher in hyperinsulinemic, insulin-resistant subjects (1.73+/-0.39 versus 0.88+/-0.13 mg/kg per day; P<0.05) and correlated with fasting plasma insulin concentrations (r=0.558; P=0.038), despite great heterogeneity in apoB-48 kinetic parameters, particularly among the obese subjects. There was no significant difference in clearance of apoB-48 between the 2 groups, nor was there a significant correlati...Continue Reading

References

Jun 12, 1999·European Journal of Clinical Nutrition·M K Hellerstein
Aug 23, 2000·The Journal of Clinical Investigation·H N Ginsberg
Aug 14, 2001·American Journal of Physiology. Endocrinology and Metabolism·J C MamoS Pal
Dec 6, 2001·Metabolism: Clinical and Experimental·K HigashiF Ohsuzu
Jun 22, 2002·Metabolism: Clinical and Experimental·Catherine PhillipsGerald H Tomkin
Jul 18, 2002·Atherosclerosis·Hirofumi OhnishiKazuaki Shimamoto
Sep 28, 2002·Current Opinion in Lipidology·Spencer D ProctorJohn C L Mamo
Jul 10, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Francine K WeltyErnst J Schaefer
Sep 18, 2004·Metabolism: Clinical and Experimental·Marcelo C BatistaJulian B Marsh
Feb 25, 2005·Current Atherosclerosis Reports·ThB TwicklerJ S Cohn
May 14, 2005·Current Opinion in Lipidology·M Mahmood HussainJahangir Iqbal
Aug 17, 2005·Current Medicinal Chemistry·Genovefa D KolovouDennis V Cokkinos

❮ Previous
Next ❯

Citations

Oct 19, 2006·Current Atherosclerosis Reports·Robert H KnoppPathmaja Paramsothy
Jan 25, 2013·Current Atherosclerosis Reports·D C ChanG F Watts
May 8, 2008·Current Opinion in Lipidology·Khosrow Adeli, Gary F Lewis
Dec 14, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Scott D ZawiejaMariappan Muthuchamy
Jun 17, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Mirjana PavlicGary F Lewis
Jun 28, 2012·Journal of Lipid Research·Tomomi YamazakiOsamu Ezaki
Jun 27, 2009·Journal of Atherosclerosis and Thrombosis·Chizuko MaruyamaTaro Maruyama
Sep 23, 2014·Metabolism: Clinical and Experimental·Liya Wu, Klaus G Parhofer
Mar 29, 2014·Current Medical Research and Opinion·Angela PirilloAlberico Luigi Catapano
Sep 15, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Carolina Gutierrez-RepisoEduardo Garcia-Fuentes
May 15, 2015·Annual Review of Nutrition·Satya DashGary F Lewis
Jul 26, 2008·Atherosclerosis. Supplements·Joanne HsiehKhosrow Adeli
Nov 13, 2014·Journal of Lipid Research·Emile Levy
Dec 13, 2017·European Journal of Clinical Investigation·Benjamin BurggraafManuel Castro Cabezas
Jun 28, 2018·Journal of Lipid Research·Jean-Philippe Drouin-ChartierPatrick Couture
Jan 11, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Alain VeilleuxEmile Levy
Feb 7, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Juan-Patricio NogueiraRené Valéro
Apr 12, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Changting XiaoGary F Lewis
Sep 28, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Satya DashGary F Lewis
Aug 12, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Nadège PadillaRené Valéro
Nov 14, 2015·Diabetes & Metabolism Journal·Klaus G Parhofer
Jan 12, 2016·PloS One·Niina MatikainenMarja-Riitta Taskinen
Jul 18, 2017·BMJ Open Diabetes Research & Care·Miguel Ángel Gómez-SámanoFrancisco J Gómez-Pérez
Apr 7, 2010·Nature Reviews. Gastroenterology & Hepatology·Jung Sub LimRobert H Lustig
Jan 3, 2015·Endocrine Reviews·Gary F LewisRobert A Hegele
Feb 7, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sandra Jimena Hernández VallejoJean-Marc Lacorte
May 31, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Melanie A FontaineSpencer D Proctor

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.