PMID: 7036808Nov 1, 1981Paper

Hyperinsulinism and peripheral resistance to insulin in a case of leprechaunism

Anales españoles de pediatría
N LambruschiniF R Hierro

Abstract

The study of hydrocarbonated metabolism in a newly born affected by leprechaunism is presented. Glycemia throughout the day and with a diet rich in carbohydrates (80 g/day) fluctuated between hyperglycemic (295 mg/dl) and hypoglycemic (37 mg/dl) figures. When ingestion of carbohydrates was reduced to half and the intake fractioned these fluctuations dissappeared. After a glucose overdose (3 g/kg IV) insuline figures were permantely high (from 315 IV/ml to 251 IV/ml). Exogen insulin test (0,1 IU/kg IV) did not reduce glycemia to an improtant level (time 0: 187 mg/dl; time 60: 129 mg/dl). The administration of glucagon (0.3 mg/kg did not normally raise glycemia (35, 54, 31 and 41 mg/dl in times 0', 30', 60 and 120'). In the studied case existed an intolerance to diets rich in carbohydrates, hyperinsulinism and lack of response to insulin and glucagon. Insulino-resistance seems to be of the peripheral type because neither elevated figures of antagonists nor presence of antiinsulin antibodies were detected and the response to exogen insulin was diminished. The underdevelopment of these patients seems to depend upon the alterations of the hydrocarbonates metabolism and the simple improvement of it by means of dietetic measures seems...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.