PMID: 7016059May 1, 1981Paper

Hyperkalemia associated with indomethacin

Archives of Internal Medicine
R C GoldszerA B Schwartz

Abstract

Substantial hyperkalemia with ECG abnormalities developed in a patient. None of the common causes of hyperkalemia was found, eg, acidosis, hemolysis, rhabdomyolysis, renal failure, hypoadrenalism, leukocytosis, or thrombocytosis. The patient had been receiving indomethacin, a drug known to inhibit renin production, aldosterone excretion, and prostaglandin synthetase. The patient was rechallanged with indomethacin, and measurements of serum potassium and renin, urinary potassium, aldosterone, and creatinine levels were done. The study period clearly showed a hyporeninemic-hypoaldosterone states with diminished renal potassium excretion, leading to hyperkalemia associated with the indomethacin therapy. The development of hyperkalemia caused by indomethacin is probably unusual; however, we believe it is important to report this potentially serious pathophysiologic occurrence associated with a commonly used medication.

Citations

Nov 2, 1991·BMJ : British Medical Journal·J D Swales
Jul 13, 1985·British Medical Journal·A ZimranC Hershko
Jul 1, 1991·Journal of Clinical Pharmacology·A Whelton, C W Hamilton
Jan 1, 1983·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W L Henrich
Sep 1, 1984·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H L Corwin, J V Bonventre
Apr 17, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jean-Philippe Lafrance, Donald R Miller
May 1, 1984·Disease-a-month : DM·D C Batlle, N A Kurtzman
Jan 1, 1990·The Journal of Diabetic Complications·J UribarriH J Carroll
Jun 1, 1983·Journal of the American Geriatrics Society·D E MeierW M Bennet
Aug 1, 1986·Australian and New Zealand Journal of Medicine·A DavisE J Begg
Mar 1, 1984·The New England Journal of Medicine·D M Clive, J S Stoff
Aug 1, 1988·Baillière's Clinical Rheumatology·A L Tonkin, L M Wing
Aug 1, 1982·The American Journal of Medicine·J T HarringtonJ P Kassirer
Aug 1, 1986·Hypertension·L M RuilopeJ C Romero

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