Hyperkalemia in end-stage renal disease: mechanisms and management.

Journal of the American Society of Nephrology : JASN
M Allon

Abstract

Clinical investigations in the past few years have enhanced the understanding of the mechanisms of hyperkalemia in patients with ESRD. The results of these studies have led to modifications in the acute treatment and prevention of hyperkalemia in this patient population. They have confirmed the efficacy of intravenous insulin, while raising doubts about the utility of intravenous bicarbonate, for the acute treatment of hyperkalemia. Moreover, the beta-adrenergic agonist albuterol has been shown to be a useful adjunct to insulin for acutely lowering plasma potassium. Finally, there has been enhanced recognition of nondietary factors that can predispose to hyperkalemia in patients with ESRD, including prolonged fasting and the use of nonselective beta-adrenergic blockers. These new insights may improve the clinical management of hyperkalemia in patients with renal failure.

Citations

May 18, 2021·Mayo Clinic Proceedings. Innovations, Quality & Outcomes·Shun KohsakaToshitaka Yajima
Jan 30, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gary SirkenPeter Fumo
Jan 31, 2006·Hemodialysis International·Ramin SamTodd S Ing
Oct 31, 2006·The American Journal of Medicine·Murray Epstein
Sep 28, 2007·Seminars in Dialysis·Nirupama Putcha, Michael Allon
Oct 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M Allon, N Shanklin
Mar 11, 2009·The American Journal of Medicine·Apurv Khanna, William B White
Mar 1, 2002·Postgraduate Medicine·Gregorio T Obrador, Brian J G Pereira
Apr 20, 2010·Néphrologie & thérapeutique·Bertrand Dussol
Jul 14, 2010·Fundamental & Clinical Pharmacology·Torben Clausen
May 19, 2011·Nature Reviews. Nephrology·Ori S Better, Zaid A Abassi

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