Hyperkalemic hyperchloremic metabolic acidosis in sickle cell hemoglobinopathies

The American Journal of Medicine
D BatlleN A Kurtzman

Abstract

This report describes the occurrence of hyperkalemic hyperchloremic metabolic acidosis in six patients with sickle cell hemoglobinopathies. Three patients had sickle cell anemia, two had sickle cell trait and one had S-C disease. In all patients, decreased renal potassium excretion was demonstrated by the finding of a fractional potassium excretion lower than that of control subjects with comparable glomerular filtration rates. Two patterns of impaired urinary acidification were discerned. Four patients had a urinary pH above 5.5 in the presence of systemic acidosis and, thus, were classified a having distal renal tubular acidosis. The remaining two patients had very low rates of ammonium excretion despite intact capacity to lower urinary pH below 5.5 during systemic acidosis; this pattern was ascribed to selective aldosterone deficiency. Sickle cell hemoglobinopathies should be included in the differential diagnosis of hyperkalemic hyperchloremic metabolic acidosis.

References

Sep 15, 1977·The New England Journal of Medicine·A SebastianR C Morris
Mar 1, 1979·Annals of Internal Medicine·R A DeFronzoC R Cooke
Apr 1, 1975·Annals of Internal Medicine·T Murray, M Goldberg
Apr 1, 1974·Archives of Internal Medicine·V M Buckalew, A Someren
Dec 1, 1971·Clinical Science·H H Kong, G A Alleyne
Mar 1, 1970·Clinica Chimica Acta; International Journal of Clinical Chemistry·L W Statius van EpsL W La Porte-Wijsman
Mar 1, 1967·The Journal of Clinical Investigation·F E HatchL W Diggs
Jul 29, 1967·British Medical Journal·O O Akinkugbe
Apr 1, 1981·The American Journal of Medicine·D C BatlleN A Kurtzman
Jan 1, 1980·Kidney International·R A DeFronzo
Jan 1, 1981·Archives of Internal Medicine·S Y Tan, M Burton
Feb 12, 1981·The New England Journal of Medicine·D C BatlleN A Kurtzman
Sep 1, 1956·The Journal of Clinical Investigation·H A ITANOD THOMPSON
May 2, 1963·The New England Journal of Medicine·B R HARROWN C LIEBMAN

❮ Previous
Next ❯

Citations

Oct 1, 1988·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J Rodríguez-Soriano, A Vallo
Oct 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H K GyasiA Daar
Mar 3, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Farahnak AssadiOmid Rouhi
Jan 5, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Amy M Becker
May 31, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·A LonsdorferJ Lonsdorfer
Sep 28, 2013·La Revue de médecine interne·A SeidowskyJ Prinseau
Jan 5, 2000·Kidney International·P T PhamS Q Lew
May 25, 2002·Kidney International·Donald E Wesson
Nov 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Daniel Batlle, Syed K Haque
Feb 15, 2011·International Journal of Clinical Practice·P Reddy
Dec 17, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Paul DrawzJane Little
Oct 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D J MinerJ E Tomaszewski
Oct 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M M SalemD C Batlle
Sep 10, 2011·British Journal of Haematology·Claire C Sharpe, Swee L Thein
Dec 18, 2013·British Journal of Haematology·Santosh L SarafVictor R Gordeuk
May 1, 1984·Disease-a-month : DM·D C Batlle, N A Kurtzman
Feb 11, 2015·Nature Reviews. Nephrology·Karl A Nath, Robert P Hebbel
May 1, 1985·Kidney International·P E de Jong, L W Statius van Eps
Apr 1, 1985·Kidney International·J P Kokko
Oct 1, 1990·Kidney International·N A Kurtzman
Mar 1, 1997·Kidney International·A GuaschW E Mitch
May 1, 1986·Acta paediatrica Scandinavica·J Rodríguez-SorianoJ M Fernández-Garnica
Feb 1, 1991·Current Problems in Pediatrics·F SantosJ C Chan
Jun 29, 2000·Baillière's Clinical Haematology·S K Ballas
Jan 25, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Stéphane MaurelJean-Philippe Haymann
Nov 15, 1987·Hospital Practice·N A Kurtzman
Dec 12, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Maud CazenaveMarie Courbebaisse
Oct 1, 1995·American Journal of Hematology·M ElisafK C Siamopoulos
Jan 15, 2004·American Journal of Physiology. Renal Physiology·Wing Y LiAlan S L Yu
May 8, 1999·Journal of the American Society of Nephrology : JASN·A GuaschL J Elsas
Feb 13, 2003·The Urologic Clinics of North America·Joseph A Molitierno, Culley C Carson
Feb 6, 2007·Seminars in Nephrology·Daniel BatlleNeil Kurtzman
Jun 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D Batlle, G Flores
Dec 1, 1983·Kidney International·N A Kurtzman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.