Hyperkeratosis in cystathionine beta synthase-deficient mice: an animal model of hyperhomocysteinemia

The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology
Karine RobertNathalie Janel

Abstract

Cystathionine beta synthase (CBS) is a crucial regulator of plasma concentrations of homocysteine. Severe hyperhomocysteinemia due to CBS deficiency confers diverse clinical manifestations. Patients with severe hyperhomocysteinemia have fine hair and thin skin, but it is unclear whether these changes are related to CBS deficiency or are coincidental. To investigate these aspects of hyperhomocysteinemia, we characterized skin abnormalities of CBS-deficient mice, a murine model of severe hyperhomocysteinemia. Histological and histomorphometric analyses revealed that CBS-deficient mice have wrinkled skin with hyperkeratinosis of the epidermis and thinning of the dermis.

References

May 11, 1989·The New England Journal of Medicine
Oct 1, 1989·Experimental and Molecular Pathology·K S McCully, M P Vezeridis
Jan 1, 1987·Gerontology·J Rosenthal
Jul 1, 1968·The American Journal of Medicine·M C CareyF D McAuley
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·M WatanabeN Maeda
Apr 16, 1998·The New England Journal of Medicine·G N Welch, J Loscalzo
Feb 20, 1999·Journal of the American Academy of Dermatology·G E GibsonM R Pittelkow
Aug 23, 2000·The Journal of Clinical Investigation·R T EberhardtJ Loscalzo
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S R LentzF M Faraci
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·N WeissJ Loscalzo
Jan 10, 2002·Nature·Stuart D TynerLawrence A Donehower
Jan 15, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Norbert WeissJoseph Loscalzo
Nov 16, 2002·Circulation Research·Gary L BaumbachSteven R Lentz
Feb 18, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Karine RobertJacqueline London
Mar 1, 1965·The Journal of Pediatrics·N A CARSONG E GAULL

❮ Previous
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Citations

Nov 7, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sapna GuptaWarren D Kruger
Oct 26, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Richard S Beard, Shawn E Bearden
Nov 19, 2011·PloS One·Sapna Gupta, Warren D Kruger
Jul 8, 2009·The Pharmacogenomics Journal·D F CarrUNKNOWN FolATED study team
Jun 5, 2007·Experimental and Molecular Pathology·Julien HameletNathalie Janel
Aug 16, 2006·Seminars in Cutaneous Medicine and Surgery·Paolo Romanelli, Navid Bouzari
Nov 29, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Francesco GrassiRoberto Pacifici
Mar 6, 2018·Frontiers in Cell and Developmental Biology·Shubhangi PrabhudesaiRamani Ramchandran
Aug 2, 2015·Journal of Inherited Metabolic Disease·Sapna GuptaWarren D Kruger
Nov 6, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sapna GuptaWarren D Kruger
Jul 28, 2016·Cellular and Molecular Life Sciences : CMLS·Carmen Ehrmann, Marlon R Schneider
Oct 23, 2018·International Journal of Genomics·Kamila BorowczykHieronim Jakubowski
Jun 27, 2019·Journal of Inherited Metabolic Disease·Sapna GuptaWarren D Kruger
Dec 16, 2020·Expert Review of Proteomics·Hieronim Jakubowski
Jul 2, 2021·Nutrition & Metabolism·Christine BrüttingGabriele I Stangl

❮ Previous
Next ❯

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