Hyperleptinaemia and hypoadiponectinaemia are associated with gallstone disease

European Journal of Clinical Investigation
S N WangK T Lee

Abstract

Gallstone disease has been regarded as an obesity-related disease. Therefore, we hypothesized that leptin and adiponectin, mainly produced by adipose tissue, may play roles in gallstone disease. The RIA method was used to analyze serum leptin and adiponectin levels of 90 gallstone patients and 91 healthy subjects. Our results showed that BMI, fasting glucose, serum AST and ALT, and leptin were significantly increased in the gallstone patients as compared with the healthy subjects (P < 0.001, P < 0.001, P < 0.001, P < 0.001, P < 0.001, and P = 0.013, respectively). Intriguingly, serum adiponectin was the only variable to be significantly decreased in the gallstone patients (P = 0.002). Furthermore, serum AST, leptin, and adiponectin were significantly associated with gallstone disease (P < 0.001, P = 0.021, and P = 0.006, respectively). Overweight (BMI >or= 25 kg m(-2)), but not normal-weight, gallstone patients had an increased serum leptin and a decreased serum adiponectin level as compared with matched healthy subjects (P < 0.001 and P = 0.024, respectively). In addition, serum leptin was positively correlated with BMI and serum cholesterol, while serum adiponectin was inversely correlated with serum triglyceride in the galls...Continue Reading

References

Mar 1, 1992·The American Journal of Clinical Nutrition·M J StampferW C Willett
Apr 1, 1993·American Journal of Surgery·M C Carey
Oct 27, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A F AttiliE Scafato
Sep 11, 1998·Science·M R Sierra-HonigmannJ R Flores-Riveros
Oct 31, 1998·Nature·J M Friedman, J L Halaas
Mar 27, 2001·Postgraduate Medical Journal·M Acalovschi
Jul 12, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·S VanPattenD E Cohen
Oct 27, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C E Ruhl, J E Everhart
Feb 21, 2002·Trends in Endocrinology and Metabolism : TEM·Anders H BergPhilipp E Scherer
Mar 30, 2002·Trends in Immunology·Giuseppe MatareseSerafino Zappacosta
Apr 24, 2002·Obesity Surgery·F Xavier Pi-Sunyer
Jan 14, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Masahiro KumadaUNKNOWN Osaka CAD Study Group. Coronary artery disease
May 24, 2003·Current Diabetes Reports·Utpal B Pajvani, Philipp E Scherer
Aug 29, 2003·The Journal of Surgical Research·Khoi Q TranHenry A Pitt
Nov 6, 2003·American Journal of Surgery·Shawn P FaganDavid H Berger
Jun 24, 2004·The American Journal of Clinical Nutrition·Chung-Jyi TsaiEdward L Giovannucci
Oct 8, 2004·The British Journal of Nutrition·Paul Trayhurn, I Stuart Wood
Nov 9, 2004·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Shannon J GraewinHenry A Pitt
Jan 22, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cynthia W KoSum P Lee
Aug 11, 2005·Current Drug Targets. Immune, Endocrine and Metabolic Disorders·Nahum Méndez-SánchezMisael Uribe
Nov 8, 2005·World Journal of Gastroenterology : WJG·Nahum Méndez-SánchezMisael Uribe

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Citations

Nov 13, 2009·Journal of Gastroenterology·Juntaro MatsuzakiToshifumi Hibi
Jul 9, 2010·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Shen-Nien WangKing-Teh Lee
Jul 28, 2010·Biochemical and Biophysical Research Communications·Hideharu OgiyamaNorio Hayashi
May 12, 2009·American Journal of Surgery·Shen-Nien WangKing-Teh Lee
Nov 2, 2014·Annals of Surgical Oncology·Diogo TorresMichael R Milam
Dec 30, 2016·Journal of Veterinary Internal Medicine·S LeeW H Kim
Mar 13, 2015·The Journal of International Medical Research·Serdar SaraçNecati Yenice
Jan 1, 2016·Terapevticheskiĭ arkhiv·I V TereshchenkoA A Suslina
Jul 1, 2020·Terapevticheskiĭ arkhiv·N A CherkashchenkoT S Krolevets
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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