Hyperleptinemia as a component of a metabolic syndrome of cardiovascular risk

Arteriosclerosis, Thrombosis, and Vascular Biology
F LeyvaJ C Stevenson

Abstract

In humans, production of the adipocyte-derived peptide leptin has been linked to adiposity, insulin, and insulin sensitivity. We therefore considered that alterations in plasma leptin concentrations could constitute an additional component of a metabolic syndrome of cardiovascular risk. To explore this hypothesis, we employed factor analysis, a multivariate statistical technique that allows reduction of large numbers of highly intercorrelated variables to composite, biologically meaningful factors. Seventy-four men [age, 48.4+/-1.3 years (mean+/-SEM); body mass index (BMI), 25.6+/-0.3 kg/m2] who were free of coronary heart disease and diabetes underwent anthropometric measurements (subscapular-to-triceps [S:T] and subscapular-to-biceps [S:B] skinfold thickness ratios, measurement of fasting plasma leptin, and an intravenous glucose tolerance test (IVGTT) for assessment of insulin sensitivity. Plasma leptin concentrations were correlated with BMI (r=0.57, P<0.001), S:T (r=0.34, P=0.003), S:B (r=0.37, P<0.001), systolic and diastolic blood pressures (both r=0.24, P=0.044), fasting triglycerides (r=0.31, P=0.007), serum uric acid (r=0.35, P=0.003), fasting glucose (r=0.32, P=0.003) and insulin (r=0.33, P=0.004), and IVGTT insulin ...Continue Reading

References

Jun 1, 1979·The American Journal of Physiology·R N BergmanC Cobelli
Dec 1, 1990·Journal of Epidemiology and Community Health·G D Smith, A Phillips
Sep 1, 1995·Nature Medicine·F LönnqvistM Schalling
Feb 1, 1996·The New England Journal of Medicine·R V ConsidineT L Bauer
Mar 1, 1996·The Journal of Clinical Investigation·M K SinhaJ F Caro
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·C B Kallen, M A Lazar
Feb 1, 1997·The Journal of Clinical Endocrinology and Metabolism·A WidjajaG Brabant
May 1, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S M HaffnerM Laakso

❮ Previous
Next ❯

Citations

Feb 16, 2000·Biochemical and Biophysical Research Communications·Y ShirakuraS Kawai
Feb 17, 2000·Cellular Immunology·C Martín-RomeroV Sánchez-Margalet
Aug 1, 2006·Indian Journal of Pediatrics·Anahita HamidiBagher Larijani
Sep 27, 2005·Journal of Physiology and Biochemistry·B TresacoM Bueno
Sep 12, 2000·Current Hypertension Reports·M S Bray, E Boerwinkle
Jul 24, 2002·Clinical Biochemistry·Javier Gómez-AmbrosiGema Frühbeck
Jun 28, 2000·Nutrition·M HaluzíkR Ceska
Nov 4, 2006·Gender Medicine·Eiji OdaYoshifusa Aizawa
Dec 3, 1999·Journal of Internal Medicine·S SöderbergT Olsson
Dec 29, 2010·Journal of Medicinal Food·Meera PenumetchaSampath Parthasarathy
Apr 7, 2009·Metabolic Syndrome and Related Disorders·Maria Gabriela Valle GottliebIvana Beatrice Manica da Cruz
Sep 22, 2011·Metabolic Syndrome and Related Disorders·Dilek YazıcıSema Akalın
Apr 5, 2012·Metabolic Syndrome and Related Disorders·Alireza EsteghamatiManouchehr Nakhjavani
Mar 15, 2008·Age and Ageing·Aapo LehtonenReijo Tilvis
Apr 9, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mauro ZamboniOttavio Bosello
May 24, 2001·AIDS·H Pernerstorfer-SchoenP Quehenberger
Jun 14, 2001·Journal of Hypertension·K NarkiewiczV K Somers
Jun 19, 2004·Current Opinion in Nephrology and Hypertension·Marcelo Lima de Gusmao Correia, William Geoffrey Haynes
Aug 2, 2007·American Journal of Therapeutics·Zafar H IsrailiManuel Velasco
Jan 24, 2014·Journal of Nutrition and Metabolism·Suruchi MishraNadine R Sahyoun
Feb 26, 2010·BMC Genetics·Claudia H T TamMaggie C Y Ng
May 22, 2008·The Journal of Clinical Endocrinology and Metabolism·Erik IngelssonRamachandran S Vasan
Nov 21, 2009·The Journal of Clinical Endocrinology and Metabolism·Marina TsaoussoglouAlexandros N Vgontzas
Feb 8, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shunichi IharaMasatoshi Kawana
Oct 2, 2001·Journal of Periodontology·R B Johnson, F G Serio
Dec 21, 2006·Journal of American College Health : J of ACH·Angela M KempfTerry T K Huang
Oct 13, 2010·World Journal of Gastroenterology : WJG·Giovanni TarantinoAnnamaria Colao
Jul 3, 2010·Journal of Endocrinological Investigation·L AiraghiG Lambertenghi Deliliers
May 1, 2012·Annual Review of Nutrition·Niyati ParekhElisa V Bandera
Jul 1, 2006·Women's Health·Deborah J Clegg, Sue C Heffelfinger
Feb 3, 2000·Critical Reviews in Clinical Laboratory Sciences·J Himms-Hagen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Related Papers

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
A M HodgeK G Alberti
Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association
Reda A ElbadawySaleh Al-Amri
International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
M ValleA Suanes
© 2022 Meta ULC. All rights reserved