Hyperleukocytosis Complicated by Intracerebral Hemorrhage and Spurious Hypoxemia: A Case Report and Literature Review

A & a Case Reports
Yumi KatakuraTakahisa Goto

Abstract

We present the management of a 15-year-old girl with acute myeloid leukemia who presented with massive hyperleukocytosis and neurological deficit due to intracerebral hemorrhage. Surgical intervention was considered but ultimately not undertaken because of the presence of massive hyperleukocytosis, thrombocytopenia, hypokalemia, and considerable discrepancy between the oxygen saturation values determined mechanically and by peripheral oximetry. Aggressive treatment of the hyperleukocytosis was immediately started, which improved the patient's overall condition and rendered surgical intervention unnecessary. This report shows that immediate treatment of massive hyperleukocytosis and critical interpretation of laboratory results in patients with hyperleukocytosis are warranted.

References

Sep 1, 1969·The American Journal of Medicine·F M MuggiaE F Osserman
Aug 24, 1999·Southern Medical Journal·T F GorskiM Jacobs
Nov 18, 2004·Pediatric Blood & Cancer·Eric J LoweJohn T Sandlund
Aug 13, 2005·Critical Care Medicine·Abhijit V LeleRobert D Stevens
May 26, 2009·International Journal of Hematology·Antonio RuggieroR Riccardi
Sep 19, 2009·Paediatric Anaesthesia·Clement FongJonathan De Lima
Aug 31, 2012·BMC Medicine·Chien-Yuan ChenHwei-Fang Tien
Nov 11, 2014·Annals of Internal Medicine·Richard M KaufmanAaron A R Tobian

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Citations

Jun 19, 2020·Journal of Medical Biochemistry·Guillaume GrzychGiuseppe Lippi

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