Hyperlipidemia in children: the role of uremia, steroids and cyclosporine therapy

Nephron
A Singh, A Tejani

Abstract

At present, there are very few studies that look at the effect of uremia, prednisone and cyclosporine therapy on the lipid profiles of children. This effect is important because of the potential association of hyperlipidemia and increased risk of cardiovascular morbidity and mortality and glomerulosclerosis. We measured fasting lipid profiles in 73 children. There were 21 controls, 18 patients treated with cyclosporine and prednisone, 9 patients treated with cyclosporine alone and 25 dialysis patients. Lipoprotein (a) levels were measured using direct binding 'sandwich' ELISA. Uremic children had higher levels of triglycerides and very-low-density lipoprotein as compared with the control group. Children receiving combination of cyclosporine and prednisone also had higher total cholesterol, triglycerides, low-density lipoprotein, very-low-density lipoprotein as compared to the control group. However, children receiving cyclosporine monotherapy had lipid profiles similar to the control group. Patients receiving cyclosporine and prednisone had higher total cholesterol, high-density lipoprotein and low-density lipoprotein as compared with the dialysis group. Evaluating lipoprotein (a) levels, children on cyclosporine monotherapy ha...Continue Reading

Citations

Sep 29, 2012·Clinical Pharmacokinetics·Troels K BergmannChristine E Staatz
Mar 27, 2001·Transplantation Proceedings·A DelucchiM A Cumsille
Mar 25, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mona Khurana, Douglas M Silverstein
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Mar 27, 2001·Transplantation Proceedings·A DelucchiM A Cumsille

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