Hyperlipidemia in glycogen storage disease type III: effect of age and metabolic control.

Journal of Inherited Metabolic Disease
Angelina V BernierDavid A Weinstein

Abstract

While the presence of hyperlipidaemia in glycogen storage disease (GSD) type Ia and Ib is generally accepted, few investigators have adequately assessed lipid profiles of GSD III in children, in whom the presence of hyperlipidaemia may be most prominent. We analysed the lipid profiles in 44 GSD III patients from 6 months to 30 years of age. Hypertriglyceridaemia and hypercholesterolaemia were common in children younger than 3 years of age. Hypertriglyceridaemia correlated negatively with age, and may reflect increased severity of hypoglycaemia in this younger population. The presence of hyperlipidaemia during childhood in these patients identifies another GSD population that could be at risk for early cardiovascular disease (CVD). Consequently, the outcome of clinical trials investigating the vascular effect of hyperlipidaemia in GSD applies to types other than GSD I.

References

Dec 22, 1999·Journal of Inherited Metabolic Disease·E HershkovitzJ V Leonard
Jun 28, 2002·Free Radical Biology & Medicine·Birgit WittensteinAlfried Kohlschütter
Oct 10, 2002·European Journal of Pediatrics·Froukje L UbelsAndries J Smit
Mar 6, 2003·Reviews in Endocrine & Metabolic Disorders·Joseph I Wolfsdorf, David A Weinstein
Apr 5, 2007·Journal of Inherited Metabolic Disease·T GeberhiwotR Cramb

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Citations

Apr 10, 2013·Asian Pacific Journal of Tropical Biomedicine·Yogesh Kumar GuptaKrishnananda Prabhu
Jun 28, 2012·Disease Models & Mechanisms·Haiqing YiBaodong Sun
Aug 7, 2014·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Hanaa El-KaraksyAhmed El-Hennawy
Apr 13, 2011·The Journal of Pediatrics·David Q WangDavid A Weinstein
Dec 3, 2014·Biochemical and Biophysical Research Communications·Xin-Hua LiXin-Xin Zhang
Jun 3, 2015·Nature Reviews. Urology·Carolyn Ritterson LewDan Theodorescu
Jan 31, 2015·Journal of Inherited Metabolic Disease·Terry G J Derks, Margreet van Rijn
Mar 13, 2014·Molecular Genetics and Metabolism·Kai-Ming LiuYuan-Tsong Chen
May 24, 2011·Orphanet Journal of Rare Diseases·Roseline FroissartPhilippe Labrune
Apr 6, 2011·Journal of Pediatric Gastroenterology and Nutrition·Christine KarwowskiBenjamin L Shneider
Sep 16, 2017·Terapevticheskiĭ arkhiv·N V PolenovaA V Starodubova
Aug 26, 2014·Journal of Pediatric Endocrinology & Metabolism : JPEM·Hanaa El-KaraksyEngy Mogahed

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