PMID: 6979985Jun 1, 1982Paper

Hyperlipoproteinemia as a significant risk factor for pulmonary embolism in patients undergoing coronary artery bypass grafting

The Annals of Thoracic Surgery
E C Hanson, F H Levine

Abstract

A five-year (1975 through 1979) retrospective analysis of all cardiac surgical patients who sustained a postoperative pulmonary embolism was undertaken, and lipoprotein profiles of these patients were evaluated. Twenty-six patients (20 men and 6 women) were identified who had definite clinical, laboratory, and radiological evidence of pulmonary embolism in the postoperative period. Twenty had undergone coronary artery bypass grafting, and the remaining 6 had undergone other cardiac surgical procedures. Of the 20 patients who had coronary bypass, 19 (95%) were found to have hyperlipoproteinemia (14 patients with type II and 5 with type IV). There were 4 hospital deaths (15%), all related to pulmonary embolism. The 4 patients had undergone coronary bypass procedures, and all had type II hyperlipoproteinemia. Since patients with hyperlipoproteinemia made up less than 10% of the coronary bypass population, the incidence of pulmonary embolism in this group is highly significant (p less than 0.001). Experimental evidence has shown that patients with hyperlipoproteinemia, especially type II, have increased platelet adhesiveness and aggregation, and coagulation abnormalities consistent with a hypercoagulable state. This retrospective s...Continue Reading

Citations

Oct 1, 1995·Catheterization and Cardiovascular Diagnosis·R S RamosR Leidenfrost
Mar 15, 1993·Journal of the American College of Cardiology·M JosaG V Sharma
Jun 17, 1998·Journal of the American College of Cardiology·D B BriegerE J Topol
Apr 20, 2011·The International Journal of Cardiovascular Imaging·Chang Keun LeeSam-Sae Oh
Feb 16, 2011·Journal of Cardiac Surgery·Aristotle D ProtopapasThanos Athanasiou
Jun 1, 1992·The Annals of Thoracic Surgery·A M GillinovD E Cameron
Dec 29, 2000·Current Opinion in Cardiology·D Schuller, L E Morrow

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