Hyperlipoproteinemia in rats fed polychlorinated biphenyls

Journal of Nutritional Science and Vitaminology
H OdaA Yoshida

Abstract

Hypercholesterolemia due to feeding of polychlorinated biphenyls (PCB) and due to feeding of high cholesterol was compared. Rats in control group were fed a 25% casein diet, and those in PCB group or cholesterol group were fed the 25% casein diet supplemented with 0.03% PCB or 1% cholesterol and 0.25% cholic acid, respectively. Lipoprotein mass (d less than 1.21 g/ml) was higher 1.9- and 1.3-fold in rats fed PCB and cholesterol, respectively, as compared with controls. In rats fed PCB, protein, cholesterol, and phospholipid in the lipoprotein fraction markedly increased. Cholesterol-feeding resulted in the increase in pre-beta-lipoprotein cholesterol, while PCB-feeding increased alpha-lipoprotein cholesterol and slightly slow migrated pre-beta-lipoprotein cholesterol. PCB-treated rats had more apolipoprotein A-I in the lipoprotein fraction than control and cholesterol-fed rats. The data demonstrated that hyperlipoproteinemia induced by PCB is a novel alpha-lipoproteinemia and a useful model for investigating metabolism of high density lipoprotein.

Citations

Apr 17, 1998·Atherosclerosis·W K PalmerT P Johnston
Jan 4, 2001·The Journal of Nutritional Biochemistry·H OdaA Yoshida
Feb 22, 2001·The Journal of Nutritional Biochemistry·H MochizukiH Yokogoshi
Apr 17, 2015·Environmental Science and Pollution Research International·Jordan T PerkinsBernhard Hennig
Aug 5, 2017·Journal of Cardiovascular Pharmacology·Thomas P JohnstonAmirhossein Sahebkar
Dec 31, 1997·Medicine and Science in Sports and Exercise·W K PalmerT P Johnston
May 17, 2006·The Journal of Nutrition·Hiroaki Oda
Oct 26, 1999·Biochemical and Biophysical Research Communications·A KawamuraA Kakinuma
Oct 10, 2001·Bioorganic & Medicinal Chemistry Letters·V L SenaV L Lima

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