Hypermelanocytic guttate and macular segmental hypomelanosis

The British Journal of Dermatology
W WesterhofR F H J Hulsmans

Abstract

We report two sisters, 27 and 30 years of age, with a cutaneous pigmentary anomaly, which seems to be a new entity. At the age of 26 years the elder sister developed an asymptomatic and persistent rash consisting of discrete, grouped, round to oval, guttate and nummular, hypopigmented macules, 0.2-5 cm in diameter. The distribution of the lesions was unilateral. They were located on the right side of the thorax with a moderately sharp demarcation in the mid-line and ran in a segmental distribution over the right arm, hand and fingers. Microscopic examination of lesional skin scrapings was negative for fungi. Examination with Wood's light accentuated the lesions from the surrounding normal skin. The younger sister had experienced identical, mostly guttate, skin lesions for many years, which at examination were distributed on all extremities and buttocks, and to a lesser degree on the trunk, but here in a segmental distribution. Histological examination (Masson-Fontana staining) of lesional skin of both sisters was identical. A slightly thinned epidermis and a marked decrease in pigmentation of the epidermal basal layer was seen. Electron microscopic examination of lesional skin showed an overall linear increase of morphologicall...Continue Reading

References

Mar 1, 1988·Journal of the American Academy of Dermatology·R FalabellaJ A Arroyave
Jan 1, 1987·Journal of the American Academy of Dermatology·R FalabellaA Alzate
Oct 1, 1970·The Journal of Pediatrics·S Hurwitz, I M Braverman
Aug 22, 2000·The Journal of Investigative Dermatology·M SeibergS S Shapiro
Aug 22, 2000·Pigment Cell Research·X Wu, J A Hammer
Feb 17, 2001·The Journal of Investigative Dermatology·G Scott, Q Zhao

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Citations

Dec 13, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Somesh Gupta, Ashima Goel
Sep 30, 2016·The British Journal of Dermatology·I NeriA Patrizi
Mar 8, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·Naoki OisoAkira Kawada

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