Hypermetabolism in the cerebellum and brainstem and cortical hypometabolism are independently associated with cognitive impairment in Parkinson's disease

European Journal of Nuclear Medicine and Molecular Imaging
Dominik BlumInga Liepelt-Scarfone

Abstract

Cognitive impairment (CI) in Parkinson's disease (PD) is associated with a widespread reduction in cortical glucose metabolism and relative increases in the cerebellum and brainstem as measured using 18F-fluorodesoxyglucose (FDG) PET. We separately analysed CI-related hypermetabolism and hypometabolism in comparison with neuropsychological test performance and investigated whether increased FDG uptake is a true feature of the disease or a normalization effect. The study included 29 subjects (12 patients with PD, 10 patients with PD dementia and 7 healthy controls") who underwent FDG PET and comprehensive neuropsychological testing. Test performance across various cognitive domains was summarized in a cognitive staging score. Metabolic indices reflecting associated changes in regional cerebral glucose metabolism (rCGM) were calculated: index(-) for CI-related hypometabolism, and index(+) for CI-related hypermetabolism. We tested whether index(+) offered additional value in predicting the severity of CI in multiple regression analysis. At higher stages of CI, increased rCGM was found in the posterior cerebellar vermis and pons, associated with impaired attention, executive function and memory. Reduced rCGM was found in various co...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jul 6, 2004·Molecular Genetics and Metabolism·Kondi WongRaphael Schiffmann
Jan 16, 2007·NeuroImage·Hong YuDavid E Vaillancourt
Sep 22, 2007·Lancet Neurology·Thomas EckertDavid Eidelberg
Dec 22, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Bruno DuboisMurat Emre
Nov 11, 2008·NeuroImage·Yilong MaDavid Eidelberg
Nov 18, 2008·Neurobiology of Disease·Kathleen L Poston, David Eidelberg
Jun 3, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Inga LiepeltDaniela Berg
Jul 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christophe HabasMichael D Greicius
Jul 15, 2009·Archives of Neurology·Thilo van EimerenAntonio P Strafella
Nov 21, 2009·Journal of Cognitive Neuroscience·Juha SalmiSynnöve Carlson
Sep 28, 2010·Parkinsonism & Related Disorders·Pekka JokinenJuha O Rinne
May 17, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Nicolaas I BohnenDavid E Kuhl
Jun 23, 2011·Acta Neurologica Scandinavica·Per BorghammerAlbert Gjedde
Jul 29, 2011·Journal of Neurophysiology·Randy L BucknerB T Thomas Yeo
Aug 9, 2012·European Journal of Nuclear Medicine and Molecular Imaging·David Garcia-GarciaMaria C Rodriguez-Oroz
Nov 6, 2012·Human Brain Mapping·Keren-Happuch EJohn E Desmond
Jan 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul EdisonDavid J Brooks
Feb 14, 2013·Brain : a Journal of Neurology·Tao Wu, Mark Hallett
Jun 22, 2014·Brain : a Journal of Neurology·Rafael González-RedondoMaría C Rodríguez-Oroz
Jun 11, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sanne K MelesDavid Eidelberg
Dec 25, 2015·NeuroImage. Clinical·Alison C SimioniLesley K Fellows
May 4, 2017·Neuro-degenerative Diseases·Margot Samson, Daniel O Claassen
Jul 21, 2017·NPJ Parkinson's Disease·Roberta BiundoAngelo Antonini

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Citations

Aug 3, 2019·Alcoholism, Clinical and Experimental Research·Ludivine RitzAnne Lise Pitel

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