Hypermethylation at 9q32-33 tumour suppressor region is age-related in normal urothelium and an early and frequent alteration in bladder cancer

Oncogene
T HabuchiT Kato

Abstract

Transcriptional silencing by CpG island hypermethylation of gene regulatory regions is one mechanism for inactivation of tumour suppressor genes. Chromosome 9q deletion is frequently found in transitional cell carcinoma (TCC) of the bladder and upper urinary tract and one of the putative tumour suppressor loci has been mapped to 9q32-33. A gene designated as DBCCR1 was identified in the candidate region and its mRNA expression is thought to be suppressed by hypermethylation. To understand the role of hypermethylation in TCC, we evaluated the methylation status of 20 CpG sites of the DBCCR1 5'-CpG island region in a total of 69 tumours from 45 patients, 21 normal urothelial specimens, and six bladder cancer cell lines. Aberrant hypermethylation levels were found in 36 (52%) of 69 tumours without any association with tumour grade or stage. Methylation was weakly detected in the normal urothelium in association with ageing. Although recurrent tumours tended to have higher methylation levels than the initial tumours, the methylation pattern was mostly maintained between multifocal TCCs in individual patients. The results suggest that hypermethylation of the DBCCR1 region is one of the earliest alterations in the development of TCCs...Continue Reading

References

Mar 12, 1992·The New England Journal of Medicine·D SidranskyB Vogelstein
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M FrommerC L Paul
May 24, 1990·Biochimica Et Biophysica Acta·H Cedar, A Razin
Jul 20, 1987·Journal of Molecular Biology·M Gardiner-Garden, M Frommer
Aug 1, 1994·Molecular and Cellular Biology·C L Hsieh
Jun 1, 1995·Current Opinion in Genetics & Development·S H Cross, A P Bird
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·J G HermanW M Linehan
Sep 7, 1994·Journal of the National Cancer Institute·T HabuchiO Yoshida
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·J P IssaS B Baylin
May 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C MaesawaR Satodate
Feb 13, 1999·Nature Genetics·P A Jones, P W Laird
Mar 24, 1999·Trends in Genetics : TIG·P A Jones
Jun 9, 1999·British Journal of Cancer·J S AveyardM A Knowles
Dec 10, 1999·Critical Reviews in Oncology/hematology·J P Issa

❮ Previous
Next ❯

Citations

Dec 4, 2004·Cancer Immunology, Immunotherapy : CII·Masanobu KitagawaKatsuiku Hirokawa
Aug 16, 2008·International Journal of Clinical Oncology·Hideki Enokida, Masayuki Nakagawa
Aug 16, 2008·International Journal of Clinical Oncology·Margaret A Knowles
Jan 26, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Marta Sánchez-Carbayo
Dec 10, 2002·Mechanisms of Ageing and Development·Yasuhito Yuasa
Feb 12, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kirsten GrønbaekPer Guldberg
Mar 7, 2009·Nature Clinical Practice. Urology·John A Taylor, George A Kuchel
Sep 22, 2005·Journal of the National Cancer Institute·Edward Giovannucci, Shuji Ogino
Apr 9, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Shawn M WnekA Jay Gandolfi
Oct 13, 2006·Current Opinion in Gastroenterology·Lanlan Shen, Jean-Pierre J Issa
May 19, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Woonbok ChungJean-Pierre J Issa
Mar 15, 2006·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Gerard J NuovoAlbert de la Chapelle
Apr 22, 2009·Expert Review of Molecular Diagnostics·Wun-Jae Kim, Yong-June Kim
Sep 17, 2014·The Kaohsiung Journal of Medical Sciences·Onur TelliMuzaffer Eroglu
Oct 19, 2010·Seminars in Cancer Biology·Jesse J Salk, Marshall S Horwitz
Jul 9, 2010·Urologic Oncology·Peter J Goebell, Margaret A Knowles
Mar 11, 2005·Journal of Cellular Biochemistry·Wun-Jae Kim, Changyi Quan
Sep 22, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Tomonori Habuchi
Jul 15, 2004·Annals of the New York Academy of Sciences·Hannes M MüllerMartin Widschwendter
Jun 16, 2009·BJU International·Véronique PhéMorgan Rouprêt
Jun 10, 2003·International Journal of Cancer. Journal International Du Cancer·Xiao-Qiong LiuYi-Xin Zeng
Mar 25, 2006·International Journal of Cancer. Journal International Du Cancer·Wolfgang A Schulz
Jul 19, 2006·British Journal of Haematology·Edurne San José-EnérizFelipe Prósper
Nov 29, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Kirsten GrønbaekPeter A Jones
Jun 14, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Paul LochheadShuji Ogino
Oct 2, 2013·Clinical Epigenetics·Steven S Smith
Jan 9, 2004·Oncogene·Kate O WrightJay E Reeder
Mar 5, 2005·Human Molecular Genetics·Hiroyuki IzumiIssei Imoto
Dec 5, 2008·Scandinavian Journal of Urology and Nephrology. Supplementum·Margaret A Knowles
Jun 21, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tao Ni, Robert J C Gilbert
Aug 7, 2002·The Journal of Nutrition·Jean-Pierre Issa
Sep 27, 2014·Molecular Biology Reports·Knud LarsenChristian Bendixen
May 17, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·David M EuhusCheryl M Lewis
Mar 9, 2010·Molecular Cancer·Victoria K HillFarida Latif

❮ Previous
Next ❯

Related Concepts

Related Feeds

Genetics & Epigenetics of Aging

Dozens of genes are implicated in lifespan, and epigenetic changes during aging affect cell function. This feed focuses on the genetics and epigenetics of aging.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.