PMID: 9450810Feb 5, 1998Paper

Hypermethylation of the M27beta (DXS255) locus in chronic B-cell leukaemia

British Journal of Haematology
P E Crossen, M J Morrison

Abstract

We have investigated the methylation status of the M27beta (DXS255) locus in 21 female patients with chronic B-cell leukaemia and in 20 normal controls. DNA was digested with Pst1 and then with the methylation sensitive enzyme HpaII and probed with the M27beta probe. Eight patients (38%) showed hypermethylation of the M27beta locus which was not seen in any of the normal controls. Hypermethylation of the M27beta locus has also been found in acute myeloid leukaemia, acute lymphocytic leukaemia and lymphoma, suggesting that hypermethylation of the M27beta locus is associated with the leukaemic process.

Citations

Jul 27, 2002·Cancer Letters·Laura J Rush, Christoph Plass
Oct 18, 2008·Current Problems in Cancer·Carla KurkjianAnthony J Murgo
Jul 15, 2005·Seminars in Hematology·Jean-Pierre J Issa, John C Byrd
Jun 27, 2007·The Journal of Molecular Diagnostics : JMD·Michaël BoudewijnsAnton W Langerak

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