Hypermethylation of the TSLC1/IGSF4 promoter is associated with tobacco smoking and a poor prognosis in primary nonsmall cell lung carcinoma

Cancer
Shinji KikuchiYoshinori Murakami

Abstract

The tumor suppressor gene TSLC1/IGSF4 on chromosomal region 11q23 is frequently inactivated by promoter methylation in various cancers, including nonsmall cell lung carcinoma (NSCLC). Several studies have demonstrated that the hypermethylation of the CpG islands of genes, including tumor suppressors, is associated with exposure to tobacco smoke. The purpose of this study was to investigate the possible association of TSLC1/IGSF4 methylation with tobacco smoking as well as with the clinical characteristics of tumors using a large number of primary NSCLC. The promoter methylation of TSLC1/IGSF4 was analyzed in 103 primary NSCLC. TSLC1/IGSF4 expression was examined by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry, whereas its methylation status was determined by bisulfite single-strand conformation polymorphism (SSCP) coupled with bisulfite sequencing. The TSLC1/IGSF4 promoter was methylated in 45 (44%) of 103 primary NSCLC. Methylation was observed in all histologic subtypes of NSCLC, including adenocarcinoma (29 of 68, 43%), squamous cell carcinoma (14 of 26, 54%), adenosquamous carcinoma (1 of 2, 50%), and large cell carcinoma (1 of 7, 14%). The incidence of methylation in tumors was signific...Continue Reading

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M FrommerC L Paul
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·S A BelinskyJ P Issa
Mar 1, 1997·Molecular and Cellular Biology·D S SwaffordS A Belinsky
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y MurakamiR H Reeves
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·S A BelinskyJ G Herman
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·W N RomK M Tchou-Wong
Mar 30, 2001·Nature Genetics·M KuramochiY Murakami
May 3, 2001·Journal of the National Cancer Institute·D G BurbeeJ D Minna
Jun 7, 2002·The Journal of Biological Chemistry·Mari MasudaYoshinori Murakami
Jun 25, 2002·Japanese Journal of Cancer Research : Gann·Hiroshi FukuharaYoshinori Murakami
Apr 30, 2003·Japanese Journal of Cancer Research : Gann·Teiichiro HondaYoshinori Murakami
Aug 15, 2003·International Journal of Cancer. Journal International Du Cancer·Sonata JarmalaiteKirsti Husgafvel-Pursiainen
Aug 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Akihiko ItoYukihiko Kitamura
Aug 20, 2003·International Journal of Cancer. Journal International Du Cancer·Takeshi FukamiYoshinori Murakami
Nov 25, 2003·The New England Journal of Medicine·James G Herman, Stephen B Baylin
Nov 26, 2003·Molecular Carcinogenesis·Angela Bik-Yu HuiDolly P Huang
Feb 19, 2004·Journal of the National Cancer Institute·Renske D M SteenbergenPeter J F Snijders
Dec 18, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Eduardo De StefaniMaría Mendilaharsu
Apr 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shinji KikuchiYoshinori Murakami

❮ Previous
Next ❯

Citations

May 15, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ricardo Santiago GomezPaula Rocha Moreira
Jun 9, 2012·Breast Cancer Research and Treatment·L JohnsonI S Fentiman
Jan 26, 2010·Cancer Metastasis Reviews·Gerwin HellerSabine Zöchbauer-Müller
Jun 12, 2013·Carcinogenesis·Zdenko HercegChristopher P Wild
Apr 28, 2007·The Cancer Journal·David S SchrumpDao M Nguyen
Oct 17, 2007·Gut·William M Grady
Feb 3, 2009·Internal Medicine·Fumio OmataTetsuya Mine
May 18, 2011·Journal of Oncology·Alexander SalskovHubert Vesselle
Apr 30, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Meijin HuangYajun Guo
Dec 3, 2011·Expert Review of Molecular Diagnostics·Shahnaz Begum
Feb 19, 2011·Cancer Investigation·Qi-Lian LiangBi-Rong Wang
Sep 27, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Osamu UeharaFutoshi Nakazawa
Aug 8, 2009·Journal of Clinical Periodontology·Naila F P OliveiraAna Paula de Souza
Aug 30, 2008·International Journal of Cancer. Journal International Du Cancer·Kiyohiro AndoAkira Nakagawara
Mar 28, 2008·Journal of Cellular and Molecular Medicine·Christina PiperiAthanasios G Papavassiliou
Nov 29, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Kirsten GrønbaekPeter A Jones
Jun 22, 2007·International Journal of Cancer. Journal International Du Cancer·Ian M SmithJoseph A Califano
Nov 11, 2010·Veterinary and Comparative Oncology·F TaylorT Scase
Nov 6, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Jun DangQin-Tao Wang
May 6, 2011·International Journal of Cancer. Journal International Du Cancer·Masayoshi NagataYoshinori Murakami
Mar 21, 2012·Cancer Science·Shinji KikuchiYoshinori Murakami
Jan 4, 2012·International Journal of Cancer. Journal International Du Cancer·Xavier TekpliSteen Mollerup
Apr 2, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Scott M LangevinKarl T Kelsey
Nov 2, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Charoenchai PuttipanyalearsNakarin Kitkumthorn
Feb 5, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Thomas HillemacherMichael Linnebank
Nov 12, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Remco M van den BergRenske D M Steenbergen
Nov 26, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Emilija VeljkovicWanjiang Han
Feb 19, 2005·Critical Reviews in Oncology/hematology·P VielhJ-C Soria

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

International Journal of Cancer. Journal International Du Cancer
Takeshi FukamiYoshinori Murakami
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Guofen YangDan Xie
Breast Cancer Research and Treatment
Gerwin HellerSabine Zöchbauer-Müller
© 2021 Meta ULC. All rights reserved