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Hypermutable non-synonymous sites are under stronger negative selection

PLoS Genetics

Nov 1, 2008

Steffen SchmidtShamil R. Sunyaev

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Abstract

Mutation rate varies greatly between nucleotide sites of the human genome and depends both on the global genomic location and the local sequence context of a site. In particular, CpG context elevates the mutation rate by an order of magnitude. Mutations also vary widely in their effect ...read more

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  • Hypermutable non-synonymous sites are under stronger negative selection

    PLoS Genetics

    Nov 1, 2008

    Steffen SchmidtShamil R. Sunyaev

    PMID: 19043566

    DOI: 10.1371/journal.pgen.1000281

    Abstract

    Mutation rate varies greatly between nucleotide sites of the human genome and depends both on the global genomic location and the local sequence context of a site. In particular, CpG context elevates the mutation rate by an order of magnitude. Mutations also vary widely in their effect ...read more

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    • References36
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