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Hypermutable non-synonymous sites are under stronger negative selection

PLoS Genetics

Nov 1, 2008

Steffen SchmidtShamil R. Sunyaev

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Abstract

Mutation rate varies greatly between nucleotide sites of the human genome and depends both on the global genomic location and the local sequence context of a site. In particular, CpG context elevates the mutation rate by an order of magnitude. Mutations also vary widely in their effect ...read more

Mentioned in this Paper

Pongo
Pongo pygmaeus
Amino Acid [EPC]
Macaca
Intergenic Region
Single Nucleotide Polymorphism
Genetic Polymorphism
Mutation Abnormality
Pan troglodytes
Genome
Paper Details
References
  • References36
  • Citations13
12

Hypermutable non-synonymous sites are under stronger negative selection

PLoS Genetics

Nov 1, 2008

Steffen SchmidtShamil R. Sunyaev

PMID: 19043566

DOI: 10.1371/journal.pgen.1000281

Abstract

Mutation rate varies greatly between nucleotide sites of the human genome and depends both on the global genomic location and the local sequence context of a site. In particular, CpG context elevates the mutation rate by an order of magnitude. Mutations also vary widely in their effect ...read more

Mentioned in this Paper

Pongo
Pongo pygmaeus
Amino Acid [EPC]
Macaca
Intergenic Region

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Paper Details
References
  • References36
  • Citations13
12

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