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Hypermutable non-synonymous sites are under stronger negative selection

PLoS Genetics

Dec 2, 2008

Steffen SchmidtS Sunyaev

Abstract

Mutation rate varies greatly between nucleotide sites of the human genome and depends both on the global genomic location and the local sequence context of a site. In particular, CpG context elevates the mutation rate by an order of magnitude. Mutations also vary widely in their effect ...read more

Mentioned in this Paper

RCHY1 gene
Exertion
Genome
Amino Acids, I.V. solution additive
Genome Assembly Sequence
Molecular_function
Sample Fixation
Pongo
Etiology
De Novo Mutation
Paper Details
References
  • References36
  • Citations16
1234
  • References36
  • Citations16
12

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Hypermutable non-synonymous sites are under stronger negative selection

PLoS Genetics

Dec 2, 2008

Steffen SchmidtS Sunyaev

PMID: 19043566

DOI: 10.1371/journal.pgen.1000281

Abstract

Mutation rate varies greatly between nucleotide sites of the human genome and depends both on the global genomic location and the local sequence context of a site. In particular, CpG context elevates the mutation rate by an order of magnitude. Mutations also vary widely in their effect ...read more

Mentioned in this Paper

RCHY1 gene
Exertion
Genome
Amino Acids, I.V. solution additive
Genome Assembly Sequence
Molecular_function
Sample Fixation
Pongo
Etiology
De Novo Mutation

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Parasite evolution

Parasite evolution involves the heritable genetic changes that a parasite accumulates during its life time. Discover the latest research on parasite evolution here.

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Discover the latest genomics research in this collection of the top open access genomics journals.

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Genome Biology and Evolution

Time dependency of molecular evolutionary rates? Yes and no

Genome Biology and EvolutionOctober 22, 2011
Sankar Subramanian, David M Lambert
Genome Research

Why do human diversity levels vary at a megabase scale?

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Paper Details
References
  • References36
  • Citations16
1234
  • References36
  • Citations16
12
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