Hypermutation in mantle cell lymphoma does not indicate a clinical or biological subentity

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Margit SchradersJohan H J M van Krieken

Abstract

Mantle cell lymphoma is a prime example of a well-defined entity based on morphology, phenotype, genetics and also clinical features. Although most patients have an adverse clinical course, some have a better survival than others. The most consistently reported adverse prognostic parameter is a high mitotic rate. Recently, it has been shown that hypermutation in the immunoglobulin heavy-chain gene occurs in a subset of mantle cell lymphomas. It is, however, unclear whether the mutational status is stable over time within a given case, whether hypermutation might be influenced by therapy and how it is related to other relevant biological features of mantle cell lymphoma. In this study, we analyzed 23 typical mantle cell lymphoma cases with respect to mutational status and compared the results with clinicopathological and genetic data to determine whether the presence of mutation indicates a subentity with clinical or pathological relevance. We found somatic hypermutation in 26% of our cases and, interestingly, one case showed ongoing somatic hypermutation. In tumor cells of both mutated and unmutated cases, we found a preferential usage of V(H)3-21 (23%) and V(H)4-34 (19%). No significant correlations were found between mutation...Continue Reading

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Citations

Aug 13, 2013·Seminars in Cancer Biology·Lesley-Ann SuttonKostas Stamatopoulos
Sep 29, 2011·Seminars in Cancer Biology·Karin E Smedby, Henrik Hjalgrim
Jul 26, 2011·Seminars in Hematology·Peter Martin, John Leonard
Apr 7, 2015·The American Journal of Pathology·Aliki XochelliKostas Stamatopoulos
Mar 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Simon A J RuleRoger G Owen
Oct 19, 2017·Journal of Hematology & Oncology·Michael FichtnerMartin Trepel
Dec 17, 2017·Journal of Experimental & Clinical Cancer Research : CR·Haige YeMichael L Wang
Aug 25, 2010·Advances in Anatomic Pathology·Michele Roullet, Adam Bagg
Aug 21, 2020·Hematological Oncology·I Della StarzaUNKNOWN Fondazione Italiana Linfomi (FIL) MRD Network
Apr 17, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raghuveer RanganathanGianpietro Dotti

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