PMID: 13920001May 1, 1962

Hypernatraemia in cerebral disorders

Journal of Clinical Pathology


Six patients are described in whom cerebral damage was associated with raised plasma sodium and chloride concentrations and with extremely low urinary outputs of sodium and chloride. The patients were not clinically dehydrated and direct determinations showed that the blood and plasma volumes, the endogenous creatinine clearance, and the urinary output of antidiuretic hormone were normal. For these and other reasons it is concluded that the metabolic picture results not from diminished circulatory volume, water deficiency, sodium deficiency, undetected diabetes insipidus or osmotic diuresis, but from the cerebral damage itself. In these and other cited cases, the cerebral damage was localized chiefly in the frontal lobes, hypothalamus or lower brain-stem, thus suggesting a descending pathway, the relationship of which to the pineal area controlling aldosterone secretion requires clarification.


Dec 1, 1953·The American Journal of Medicine·T D ULLMANN
Mar 27, 1954·Lancet·W H TAYLOR
Apr 10, 1954·Lancet·J H CORT
Aug 1, 1954·The American Journal of Medicine·F L ENGEL, C JAEGER
Jan 1, 1955·A.M.A. Archives of Internal Medicine·H M SCHOOLMANW S HOFFMAN
Jan 1, 1955·Acta Medica Scandinavica·A ELLIOT
Apr 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·B L WISE
Jan 1, 1957·British Medical Bulletin·O WRONG
Oct 1, 1957·The American Journal of Medicine·G L GORDON, F GOLDNER
Nov 1, 1958·The Journal of Clinical Investigation·J T AUGUSTG W THORN
Sep 1, 1958·The British Journal of Surgery·W H TAYLOR, J V REID
Aug 1, 1955·A.M.A. Archives of Internal Medicine·S NATELSON, M O ALEXANDER
Nov 10, 1951·British Medical Journal·W H TAYLOR
Jul 1, 1952·The Journal of Clinical Endocrinology and Metabolism·I S COOPER, P H CREVIER
Sep 1, 1952·A.M.A. Archives of Internal Medicine·L G WELTJ P PETERS
Dec 1, 1949·Annals of Internal Medicine·W T GOODALE, T D KINNEY
Nov 1, 1941·The Journal of Clinical Investigation·J W NadalW G Maddock
Apr 4, 1944·The Journal of Physiology·R A McCanceD A Black
Feb 14, 1939·The Journal of Physiology·R A McCance, E M Widdowson
Aug 14, 1939·The Journal of Physiology·R L NobleP C Williams
Sep 2, 1948·The New England Journal of Medicine·J P PETERS


Jan 1, 1979·Acta neurochirurgica·D d'AvellaG Trincia
Oct 1, 1964·Indian Journal of Pediatrics·R K CHAUDHURI
Dec 5, 1975·Brain Research·B AnderssonF Lishajko
Jan 1, 1970·Journal of Clinical Pathology. Supplement (Royal College of Pathologists)·C S Treip
Aug 1, 1966·Journal of Neurology, Neurosurgery, and Psychiatry·M BuckellM Sarner
Jan 1, 1971·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·R Okamura, J W Rohen
Oct 1, 1975·Medicine, Science, and the Law·R A GoodbodyT R Gamlen
Aug 1, 1965·Journal of the American Geriatrics Society·M I SALOMONN FRENKIEL

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