PMID: 9426914Aug 1, 1997Paper

Hypernatremia deepens the demarcating borderline of leukocytic infiltration in the burn wound

Burns : Journal of the International Society for Burn Injuries
T KurodaM Kobayashi

Abstract

The influence of hypernatremia on progressive burn wound necrosis was evaluated in a second-degree burn model. The depth of the burned tissue sloughed off was measured in a comparative study in the rat (contact burn injury with a metal plate, 70 degrees C for 5 s). Rats in the hypernatremic group were treated with an intraperitoneal fluid injection of hypernatremic saline (10 ml, 850 mEq/l). Control rats were injected with hyponatremic saline (10 ml, 100 mEq/l). On the fourth postburn day specimens were harvested and compared. The greatest depth of leukocytic infiltration (percent of total dermal thickness) was measured. The average depths were significantly different. In zone 1 (from the normal skin edge to 5 mm inside the wound) the average depth in the hypernatremic group was 38.0 +/- 9.3 percent of the dermal depth and in the control group 9.5 +/- 1.2 percent. In zone II (from 5 to 10 mm inside the wound) the hypernatremic group sloughed off at 64.0 +/- 11.8 percent and the control group at 12.5 +/- 2.1 percent. The hypernatremic group showed a deeper demarcating borderline of leukocytic infiltration than the control rats. The wound depth progression may be caused by an osmotic injury.

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Citations

Apr 15, 2004·Burns : Journal of the International Society for Burn Injuries·L-P KamolzM Frey
Jun 13, 1998·Burns : Journal of the International Society for Burn Injuries·T HaradaM Kobayashi
Nov 29, 2014·Plastic Surgery International·Gabriel DjedovicHildegunde Piza-Katzer
May 29, 1999·AACN Clinical Issues·E de GuzmanK L Mattox
Sep 30, 2014·Clinical and Experimental Emergency Medicine·Jimmy Toussaint, Adam J Singer
Nov 30, 2016·BMC Complementary and Alternative Medicine·Zhi-Cheng ChenZhi-Hong Wen
Nov 29, 2015·Acute Medicine & Surgery·Kensuke NakamuraKent Doi

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