Hyperoside Attenuates Bleomycin-Induced Pulmonary Fibrosis Development in Mice

Frontiers in Pharmacology
Jizhen HuangHong Fan

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal, and chronic lung disease. There are no effective drug therapies for IPF. Hyperoside, a flavonoid glycoside, has been proven to have anti-inflammatory, anti-fibrosis, antioxidant, and anti-cancer effects. The aim of this study was to explore the role of hyperoside in bleomycin-induced pulmonary fibrosis development in mice. We established the pulmonary fibrosis model by a single intratracheal aerosol injection of bleomycin. Seven days after the bleomycin treatment, the mice were intraperitoneally administered with hyperoside for 14 days. We found that hyperoside treatment ameliorated fibrotic pathological changes and collagen deposition in the lungs of mice with bleomycin-induced pulmonary fibrosis. Hyperoside treatment also reduced the levels of MDA, TNF-α, and IL-6 and increased the activity of SOD. In addition, hyperoside might inhibit the epithelial-mesenchymal transition (EMT) via the AKT/GSK3β pathway. Based on these findings, hyperoside attenuated pulmonary fibrosis development by inhibiting oxidative stress, inflammation, and EMT in the lung tissues of mice with pulmonary fibrosis. Therefore, hyperoside might be a promising candidate drug for the treatment of p...Continue Reading

References

Apr 1, 1988·Journal of Clinical Pathology·T AshcroftV Timbrell
Aug 31, 2001·Progress in Neurobiology·C A Grimes, R S Jope
Jul 17, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Brigham C Willis, Zea Borok
Oct 16, 2007·Chest·Chris J Scotton, Rachel C Chambers
Aug 4, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·V M FeltonB C Willis
Apr 13, 2010·Chemico-biological Interactions·Gang LiuDavid W Kamp
Apr 19, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Cecilia MarmaiPaul J Wolters
Nov 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jason R RockBrigid L M Hogan
Oct 27, 2012·The European Respiratory Journal·Wim A WuytsGeert M Verleden
Mar 3, 2015·Respiratory Medicine·Hyun Joo KimRade Tomic
May 16, 2015·The European Respiratory Journal·John HutchinsonTricia McKeever
Jan 1, 2017·Journal of Ethnopharmacology·Liu-Cheng Li, Lian-Di Kan
Jan 21, 2017·International Immunopharmacology·Peng YeCai Shi
Mar 21, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jonathan A GalliGerard J Criner
Apr 4, 2017·Lancet·Luca RicheldiMark G Jones
Apr 25, 2017·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Liyi ZouTie Wu
May 12, 2018·Molecular Medicine Reports·Yongliang ChenFeng Li
Nov 23, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xiaofang WangJinying Zhang
Apr 27, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiaobin XinJinhui Wang
Jul 13, 2019·Inflammation·Paolo CameliElena Bargagli
Jul 30, 2019·Acta histochemica·Xiao GuoWei Zhao
Nov 11, 2019·Respiratory Research·Chuyi ZhangZuoren Yu
Nov 23, 2019·International Immunopharmacology·Zhenzhen MaXiangyuan Liu
Mar 13, 2020·Comprehensive Physiology·Eva OtoupalovaVictor J Thannickal
Apr 18, 2020·Nature Reviews. Molecular Cell Biology·Jing YangUNKNOWN EMT International Association (TEMTIA)

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