Hyperoside protects against chronic mild stress-induced learning and memory deficits

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Yeli GongZhe Xiong

Abstract

Hyperoside (quercetin-3-O-b-d-galactosidepyranose) is a plant-derived flavonoid mainly found in fruits, fruit juices (most notably flavanols, flavanones, and anthocyanins) and Chinese traditional medicines. It has been applied to relieve pain and improve cardiovascular functions in clinic. However, the effects of hyperoside on cognitive impairment induced by chronic stress and the underlying molecular mechanisms remain unclear. In the current study, we used chronic mild stress (CMS) rats to investigate the effects of hyperoside on learning and memory and further explore the possible mechanisms. Our results demonstrated that hyperoside reduced the escape latency and the swimming distance of CMS rats in Morris water maze test and reversed depressive symptoms in forced swim test (FST) and sucrose preference test. In addition, hyperoside increased the expression of brain-derived neurotrophic factor (BDNF) in hippocampus of CMS rats without influencing the corticosterone (CORT) level in blood plasma. Furthermore, K252a, an inhibitor of the BDNF receptor TrkB, prevented the protective effects of hyperoside on learning and memory in CMS rats. Taken together, these results indicate that hyperoside reverses the cognitive impairment indu...Continue Reading

References

May 1, 1976·Psychological Medicine·B J CarrollJ Mendels
Jan 1, 1995·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·P E Stokes
Dec 12, 2001·British Journal of Pharmacology·M D PerloffD J Greenblatt
Mar 31, 2004·International Journal of Clinical Pharmacology and Therapeutics·A A Izzo
Aug 25, 2004·Behavioural Brain Research·Stéphanie PothionCatherine Belzung
Oct 19, 2004·Planta medica·V ButterweckH Winterhoff
Sep 2, 2006·Biological & Pharmaceutical Bulletin·Zhe XiongJianguo Chen
Oct 3, 2006·British Journal of Clinical Pharmacology·D L WhittenH Wohlmuth
Feb 10, 2007·Pharmacology, Biochemistry, and Behavior·Chao LiuJianguo Chen
Dec 1, 2007·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Corjena K CheungLinda L Halcon
Feb 26, 2008·British Journal of Clinical Pharmacology·Hiromitsu ImaiKyoichi Ohashi
Aug 17, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Siegfried KasperEugenio Aguglia
Aug 2, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Meizhu ZhengYuchi Zhang
Dec 20, 2011·Behavioural Brain Research·Amdi Sass, Gitta Wörtwein
May 23, 2012·Expert Opinion on Drug Metabolism & Toxicology·Roja Rahimi, Mohammad Abdollahi
Mar 21, 2013·Behavioural Brain Research·Estibaliz AmpueroFrancisco Javier Rubio
Jul 31, 2013·Phytotherapy Research : PTR·Emilio RussoGiovambattista De Sarro
Apr 4, 2015·Journal of Ethnopharmacology·Rena KasimuJinhui Wang
Oct 16, 2015·Stress : the International Journal on the Biology of Stress·Mei YuTao Zhang

❮ Previous
Next ❯

Citations

Oct 21, 2018·BMC Complementary and Alternative Medicine·Bruna Maria Pereira da Costa CordeiroPatrícia Maria Guedes Paiva
Jan 7, 2020·Artificial Cells, Nanomedicine, and Biotechnology·Xin-Chun QiYun-Peng Jiang
Nov 2, 2019·Current Opinion in Behavioral Sciences·Albert E Towers, Gregory G Freund
Mar 22, 2021·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Tong GuanXiujuan Zhao
Jul 24, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yajie CaiRunping Liu
Aug 21, 2021·Neurochemical Research·Huijie FanZhi Chai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.