Hyperoside protects human kidney‑2 cells against oxidative damage induced by oxalic acid

Molecular Medicine Reports
Yongliang ChenFeng Li

Abstract

The majority of renal calculi (kidney stones) are calcium stones. Oxidative damage to renal tubular epithelial cells induced by reactive oxygen species (ROS) is the predominant cause of calcium oxalate stone formation. Hyperoside (Hyp) is a flavonol glycoside extracted from medicinal plants and appears to exhibit potent antioxidant activity in various cells. The aim of the present study was to investigate the protective effect of Hyp on renal cells exposed to oxidative stress simulated by oxalic acid (OA), and to determine whether the underlying mechanism involves the nuclear factor E2‑related factor2 (Nrf2)‑antioxidative response element signaling pathway. The study determined the indicators of high oxidative stress, including ROS and hydrogen peroxide (H2O2) in human kidney‑2 cells and the results demonstrated that the levels of ROS, as evaluated by flow cytometry, and H2O2 were significantly increased following treatment with OA (5 mmol/l) for 24 h (OA group), compared with those in the untreated control group. The increased activity of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in these cells explained this observation, as it is a major source of ROS. The results demonstrated that, in the OA group, the adhe...Continue Reading

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 10, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tohru UmekawaSaeed R Khan
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yukio IshiiKiyohisa Sekizawa
Feb 21, 2006·Antioxidants & Redox Signaling·Hye-Youn ChoSteven R Kleeberger
Mar 9, 2007·American Journal of Physiology. Renal Physiology·Susan H McKiernanJudd M Aiken
May 25, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elizabeth H SidleGraeme N Smith
Aug 15, 2008·American Journal of Physiology. Renal Physiology·Michael L MerchantEleanor D Lederer
Nov 19, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Masahito HiroseKenjiro Kohri
Dec 29, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·P VanachayangkulV Butterweck
May 8, 2010·Antioxidants & Redox Signaling·Ken ItohMasayuki Yamamoto
Mar 2, 2011·Anti-cancer Agents in Medicinal Chemistry·Sumitra MiriyalaDaret K St Clair
Jun 22, 2011·Biochemical and Biophysical Research Communications·Hai-Yan XingPei-Yuan Xia
Nov 25, 2011·Hemodialysis International·Marianna ZsomEmoke Endreffy
May 24, 2013·American Journal of Physiology. Renal Physiology·Indira D PokkunuriMohammad Asghar
Jan 15, 2014·British Journal of Pharmacology·Elango BhakkiyalakshmiKunka Mohanram Ramkumar
May 24, 2014·Archives of Dermatological Research·Young LeeChang-Deok Kim
May 27, 2014·The Journal of Urology·Mathew D SorensenUNKNOWN Women’s Health Initiative Writing Group
Apr 7, 2016·Journal of Cancer Prevention·Ji Young ParkJin Won Hyun
Oct 1, 2016·Journal of Renal Injury Prevention·Mahmoud BahmaniNasrollah Naghdi

❮ Previous
Next ❯

Citations

Mar 28, 2020·Oxidative Medicine and Cellular Longevity·Kehua JiangFa Sun
Nov 17, 2020·Frontiers in Pharmacology·Jizhen HuangHong Fan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Cardiac Glycosides

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.