PMID: 7300129Sep 1, 1981

Hyperosmolality, acetate, and lactate: dilatory factors during peritoneal dialysis

Kidney International
F N MillerD B Andersen

Abstract

Factors that alter peritoneal blood flow may influence the clearance of solutes during peritoneal dialysis. Arteriolar vasodilation, for instance, could increase the delivery of solutes to the capillaries and venules leading to an increase in solute transport into the peritoneal cavity. This study was designed to identify the vasoactive effects of several major components of McGaw and Dianeal peritoneal dialysis solutions to understand how the composition of these solutions may alter in vivo blood flow in the peritoneum. Because the major differences between these solutions and Krebs solution are a high osmolality, a high dextrose concentrations, and an acetate or lactate buffer system, we investigated the effects of these components. Rats were anesthetized with the combination of urethane and chloralose. The cremaster muscles, with the nerve and blood supplies from the rat still intact, was placed in a specially designed tissue chamber that was filled with Krebs solutions. A port permitted microscopic observations of the blood vessels. In vivo television microscopy observations was used to quantitate changes in small arteriole diameters induced by changes in the composition of the solution bathing the cremaster or by the addit...Continue Reading

Citations

Oct 15, 1991·European Journal of Pharmacology·A ZhangB M Altura
May 2, 2003·Annals of Surgery·El Rasheid ZakariaJ David Richardson
Mar 12, 2005·The Journal of Trauma·El Rasheid ZakariaPatrick D Harris
Sep 1, 1984·Clinical and Experimental Pharmacology & Physiology·D N GrangerP R Kvietys
Aug 5, 2005·Journal of the American Society of Nephrology : JASN·El Rasheid ZakariaR Neal Garrison
Feb 5, 2002·The Journal of Physiology·Christian Aalkjaer
Jan 1, 1983·Kidney International·F N MillerH J Gloor
Mar 1, 1984·Kidney International·F N MillerJ N Moore
Jul 1, 1987·Kidney International·J T Daugirdas, Z M Nawab
Jun 1, 1994·Kidney International·D G StruijkL Arisz
Sep 1, 1984·Kidney International·J T Dulaney, F E Hatch
Oct 24, 2007·Surgery·El Rasheid ZakariaR Neal Garrison
Jun 28, 2016·Journal of the American College of Surgeons·Jessica L WeaverJason W Smith
Oct 24, 2015·BioMed Research International·Harald SeegerStephan Segerer
Sep 20, 2015·International Journal of Surgery·Jessica L Weaver, Jason W Smith
Nov 6, 2003·American Journal of Surgery·El Rasheid ZakariaR Neal Garrison
Jan 18, 2020·Experimental Biology and Medicine·Maksymilian OnyszkiewiczMarcin Ufnal

Related Concepts

Acetic Acids
Structure of Arteriole
Glucose, (beta-D)-Isomer
Lactates
Osmolality
Peritoneal Dialysis
Visceral Peritoneum
August Rats
Solutions
Vascular Endothelium-Dependent Relaxation

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