PMID: 9538487Apr 16, 1998Paper

Hyperosmolar nonketotic coma precipitated by lithium-induced nephrogenic diabetes insipidus

Postgraduate Medical Journal
H AzamC J Thompson

Abstract

A 45-year-old man, with a 10-year history of manic depression treated with lithium, was admitted with hyperosmolar, nonketotic coma. He gave a five-year history of polyuria and polydipsia, during which time urinalysis had been negative for glucose. After recovery from hyperglycaemia, he remained polyuric despite normal blood glucose concentrations; water deprivation testing indicated nephrogenic diabetes insipidus, likely to be lithium-induced. We hypothesize that when this man developed type 2 diabetes, chronic polyuria due to nephrogenic diabetes insipidus was sufficient to precipitate hyperosmolar dehydration.

References

Jan 1, 1992·Baillière's Clinical Endocrinology and Metabolism·W Berger, U Keller
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Citations

Jun 22, 2001·European Psychiatry : the Journal of the Association of European Psychiatrists·H BendzJ Lanke
Apr 26, 2011·The American Journal of Emergency Medicine·Chung-Wei YangSzu-Chi Wen
Feb 10, 2018·Minerva endocrinologica·Ayako ItoAtsushi Kawakami
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Patricia A DonohoueDeborah L Segaloff
Apr 5, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Camelia G GarofeanuWilliam F Clark
Oct 7, 2005·La Presse médicale·D Tran-VanB Fontaine

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