Hyperoxaluric rats do not exhibit alterations in renal expression patterns of Slc26a1 (SAT1) mRNA or protein.

Urological Research
Robert W Freel, Marguerite Hatch

Abstract

Little is known about oxalate transport in renal epithelia under basal conditions, let alone in hyperoxaluria when the capacity for renal oxalate excretion is increased. Sulfate anion transporter 1 (SAT1, Slc26a1) is considered to be a major basolateral anion-oxalate exchanger in the proximal tubule and we hypothesized its expression may correlate with urinary oxalate excretion. We quantified changes in the renal expression of SAT1 mRNA and protein in two rat models, one with hyperoxaluria (HYP) and one with renal insufficiency (HRF) induced by hyperoxaluria. The hyperoxaluria observed in the HYP group could not simply be ascribed to changes in SAT1 mRNA or protein abundance. However, when hyperoxaluria was accompanied by renal insufficiency, significant reductions in SAT1 mRNA and protein were detected in medullary and papillary tissue. Together, the results indicate that transcriptional modulation of the SAT1 gene is not a significant component of the hyperoxaluria observed in these rat models.

References

May 31, 1978·Pflügers Archiv : European journal of physiology·R GregerP Deetjen
Mar 1, 1978·The Journal of Clinical Investigation·E J WeinmanS Sansom
Apr 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D SigmonC Scheid
Jun 13, 1998·Pflügers Archiv : European journal of physiology·E BrändleR E Hautmann
Oct 12, 2000·The Journal of Urology·P S Chandhoke, J Fan
Oct 3, 2001·Physiological Reviews·D Markovich
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 19, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Katleen De PreterJo Vandesompele
Sep 10, 2002·American Journal of Physiology. Renal Physiology·Qizhi XieDavid B Mount
Oct 10, 2002·American Journal of Nephrology·Marguerite Hatch, Robert W Freel
Apr 26, 2003·DNA and Cell Biology·Ralf R RegeerDaniel Markovich
May 22, 2003·Pflügers Archiv : European journal of physiology·David B Mount, Michael F Romero
Nov 27, 2004·Urological Research·Marguerite Hatch, Robert W Freel
Apr 28, 2005·American Journal of Physiology. Renal Physiology·Mike L GreenRobert W Freel
Jun 16, 2005·Kidney International·Simone A JoostenLeendert C Paul
Jun 18, 2005·American Journal of Nephrology·Christopher J Danpure
Dec 1, 2005·Kidney International·Mike L GreenMarguerite Hatch
Dec 17, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Fabio QuondamatteoBirgitta C Burckhardt
Dec 24, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Robert W FreelManoocher Soleimani
Mar 25, 2008·Seminars in Nephrology·Marguerite Hatch, Robert W Freel
Apr 17, 2009·American Journal of Physiology. Renal Physiology·Wolfgang KrickBirgitta C Burckhardt
Feb 18, 2010·The Journal of Clinical Investigation·Paul A DawsonDaniel Markovich

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Citations

Apr 30, 2016·Pflügers Archiv : European journal of physiology·Meng WuSeth L Alper
Sep 26, 2017·The Journal of Veterinary Medical Science·Orapun JaturakanAnudep Rungsipipat
Nov 2, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jonathan M WhittamoreMarguerite Hatch

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