Sep 1, 1981

Hyperoxia and hypoxia in pregnancy: simple experimental manipulation alters the incidence of cleft lip and palate in CL/Fr mice

Proceedings of the National Academy of Sciences of the United States of America
G Millicovsky, M C Johnston


This paper describes alterations in the incidence of cleft lip and palate in CL/Fr mice subsequent to experimental manipulation of maternal respiratory oxygen levels during a critical period of pregnancy. Only a few previous studies have shown that the incidence of some "genetically determined" malformations in mammals can be decreased by environmental procedures. In addition to demonstrating a decreased incidence of cleft lip and palate subsequent to maternal hyperoxia on gestational days 10 and 11 in a genetically susceptible strain, the results of the present study show that hypoxia at this time increases the incidence of cleft lip and palate.

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  • Citations31


Mentioned in this Paper

Cleft Palate, Isolated
Gestational Age
Pregnancy Complications, Cardiovascular
Cleft Palate With Cleft Lip
Cleft Lip
Maternal-Fetal Exchange

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