Hyperoxia and tidal volume: Independent and combined effects on neonatal pulmonary inflammation

Biology of the Neonate
Carey A EhlertIkechukwu I Ekekezie

Abstract

Hyperoxia and tidal volume mechanical ventilation are independent factors in the genesis of lung injury, but it remains unclear the extent to which each is responsible or contributes to this process in newborns. To study the independent and combined effects of hyperoxia and tidal volume mechanical ventilation on the induction of lung inflammation in a newborn piglet model of ventilator-induced lung injury. Following exposure to either ambient air or F(I)O2 = 1.0 for a period of 3 days, newborn piglets were randomized to receive mechanical ventilation with either high tidal volume (20 ml/kg) or low tidal volume (6 ml/kg) for 4 h while controlling for pH. Monocyte chemoattractant protein-1 level in the lungs of animals randomized to hyperoxia with high tidal volume ventilation was significantly elevated, compared to all other groups (p < 0.05). Myeloperoxidase assayed in lung homogenate was found to be significantly higher in nonventilated animals exposed to hyperoxia (p < 0.01). Only in animals previously exposed to hyperoxia did the addition of high tidal volume ventilation further increase the level of myeloperoxidase present (p < 0.05). Pulmonary vascular resistance was significantly elevated after 4 h of mechanical ventilati...Continue Reading

Citations

Sep 14, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Patrudu S MakenaScott E Sinclair
May 8, 2007·Journal of Perinatal Medicine·David SweetUNKNOWN European Association of Perinatal Medicine
Apr 7, 2010·Clinics in Perinatology·Robert H Pfister, Jay P Goldsmith
Mar 18, 2008·Pulmonary Pharmacology & Therapeutics·Beena G SoodRaja Rabah
Mar 29, 2011·Free Radical Biology & Medicine·Dmitry KondrikovYunchao Su

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