Hyperoxic effects on alveolar sodium resorption and lung Na-K-ATPase

The American Journal of Physiology
E P CarterD H Ingbar

Abstract

Active Na+ transport by the alveolar epithelium keeps alveoli relatively dry. Hyperoxia increases epithelial permeability, resulting in pulmonary edema. We sought to determine whether active Na+ resorption from the air spaces and Na-K-ATPase activity increased in rats exposed to > 95% O2 for 60 h. The permeability x surface area products for unidirectional resorption of alveolar [14C]sucrose (PSsucrose) and 22Na+ (PSNa+) were measured in isolated, perfused rat lungs immediately after hyperoxia and after 3 and 7 days of recovery in room air. At 60 h of hyperoxia, the mean PSsucrose and PSNa+ increased from 6.71 +/- 0.8 x 10(-5) to 12.6 +/- 1.6 x 10(-5) cm3/s (P = 0.029) and from 23.6 +/- 1.1 x 10(-5) to 31.0 +/- 1.6 x 10(-5) cm3/s (P < 0.008), respectively. However, the values in individual rats ranged widely from no change to nearly a fourfold increase. Subgroup analysis revealed that benzamil- or amiloride-sensitive (transcellular) PSNa+ was significantly reduced in the exposed lungs with normal PSsucrose but was maintained in the lungs with high PSsucrose. By day 3 of recovery, mean Na+ and sucrose fluxes returned to values similar to control. Na-K-ATPase membrane hydrolytic maximal velocity (Vmax) activity fell significantly...Continue Reading

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Citations

Jun 28, 2002·Physiological Reviews·Michael A MatthayChristine Clerici
Apr 6, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·W HeberleinH Mairbäurl
Mar 11, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·M CutaiaS Rounds
Feb 24, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tsutomu SakumaMichael A Matthay
Oct 29, 2000·Journal of Applied Physiology·P FactorJ I Sznajder
Jun 17, 2008·American Journal of Respiratory and Critical Care Medicine·Maneesh BhargavaDavid H Ingbar
Oct 17, 2002·Journal of Applied Physiology·J I SznajderD H Ingbar

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