Hyperparathyroidism and long-term bone loss after renal transplantation

Clinical Transplantation
James G HeafN Fogh-Andersen

Abstract

While early bone loss after renal transplantation (RT) is well described, factors affecting the long-term fate of bone have received less attention. Whole body (WB), lumbar spine (LS) and femoral neck (FN) bone mineral density (BMD) was measured using dual energy X-ray absorptionometry in 126 stable RT patients and repeated in 114 survivors after 3 yr. Percentage change per year (%/yr) was correlated to clinical and biochemical markers of bone metabolism. Low bone mass was a marker of increased mortality (FN < 80% normal 6.3%/yr; >80% 2.2%/yr). Percent change was WB -0.7 +/- 1.5 (p < 0.01); LS -0.3 +/- 2.6; FN -1.0 +/- 3.0 (p < 0.01) and, corrected for expected loss for age and sex: WB -0.5 (p < 0.01); LS 0.0; FN -0.8 (p < 0.05). Factors associated with increased loss rates were (LS%): short RT duration [<2 yr: -3.1 (p < 0.01)], high prednisone dose [>9 mg/d: -1.9 (p < 0.01)], high cyclosporine trough concentration [>175 ng/L: -1.9 (p < 0.05)], high hyperparathyroidism (PTH) [>150 ng/L: -1.5 (p < 0.05)], high alkaline phosphatase [>275 U/L: -1.6 (p < 0.05)], high osteocalcin [>75 microg/L: -1.6 (p < 0.05)]. Marginal detrimental effects of uremia, hypoalbuminemia and hyperphosphatemia were noted. Thiazide treatment seemed to pro...Continue Reading

References

Aug 16, 1975·Lancet·R J Walton, O L Bijvoet
Jul 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·V PichetteD Ouimet
May 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G DumoulinJ Regnard
Nov 10, 1998·Transplantation·W H GrotzP J Schollmeyer
Nov 14, 1998·The Journal of Clinical Endocrinology and Metabolism·M Abdelhadi, J Nordenström
Dec 5, 1998·Transplantation Proceedings·H KimS Park
Dec 5, 1998·Transplantation Proceedings·K YazawaK Mizuno
Sep 29, 1999·Transplantation Proceedings·A MorenoF Oppenheimer
Feb 17, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A M Cueto-ManzanoA J Hutchison
May 17, 2000·Transplantation Proceedings·A UğurR Erdal
Nov 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S GianniniG Crepaldi

❮ Previous
Next ❯

Citations

Oct 25, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M Fleseriu, A A Licata
May 5, 2009·Journal of Cancer Survivorship : Research and Practice·Charles J StavaRena Vassilopoulou-Sellin
Jan 22, 2008·World Journal of Surgery·K SchlosserE Domínguez Fernández
Feb 16, 2008·The American Journal of the Medical Sciences·Rubin ZhangDouglas Slakey
Apr 21, 2005·Kidney International·Amgad E El-AgroudyMohamed A Ghoneim
Sep 1, 2009·Transplantation Proceedings·R MarcénJ Ortuño
Aug 27, 2015·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Francisco José Borrego UtielMaría Auxiliadora Mazuecos Blanca
Oct 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Oct 16, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S AkaberiG Nyberg
Mar 19, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Christa Mitterbauer, Rainer Oberbauer
Aug 4, 2006·European Journal of Clinical Investigation·K Kodras, M Haas
Jan 16, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J E NovakA Greenberg
Apr 23, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H AmerR Kumar
Sep 17, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P PerrinB Moulin
Mar 25, 2011·Pediatric Transplantation·Ali DerakhshanGhamar H Al-Hashemi
Oct 2, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Hee Jung JeonJaeseok Yang
Apr 21, 2016·The Medical Clinics of North America·Johan Daniël Nel, Sol Epstein
Jul 20, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Matthew D Griffin, Rajiv Kumar
Mar 19, 2008·Expert Opinion on Pharmacotherapy·Angel L M de Francisco
Aug 16, 2016·International Urology and Nephrology·Aygül ÇeltikErcan Ok
Feb 11, 2014·Journal of the American Society of Nephrology : JASN·Sapna P IyerThomas L Nickolas
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·José R WeisingerEzequiel Bellorin-Font
Jun 14, 2012·Postgraduate Medicine·Veeraish ChauhanEllie Kelepouris
May 7, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Stefania SellaSandro Giannini
Oct 30, 2015·Current Opinion in Endocrinology, Diabetes, and Obesity·Hee Jung JeonJaeseok Yang
Jun 25, 2020·Medicina·Karthik KovvuruVishnu Garla

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.