PMID: 15333720Aug 31, 2004Paper

Hyperphagia contributes to the normal body composition and protein-energy balance in HIV-infected asymptomatic men

The Journal of Nutrition
Pascal CrennJean-Claude Melchior

Abstract

Wasting can occur at an early stage of HIV infection. Both reduced energy intake and increased resting energy expenditure (REE) have been considered as factors in wasting with predominant lean body mass loss, suggesting disturbances of protein metabolism. Our aim was to study protein-energy metabolism in relation to body composition and oral energy intake in asymptomatic patients with HIV infection but receiving no active antiretroviral therapy. Stable-weight asymptomatic male patients (n = 8) at stage A of HIV infection with a detectable viral load were compared with 9 healthy control men. Protein metabolism was studied in the postabsorptive state using a primed constant infusion of l-[1-(13)C]leucine and l-[2-(15)N]glutamine. REE was studied by indirect calorimetry, body composition by bioelectrical impedance, and energy intake by dietary records. BMI and lean body mass did not differ between patients and controls. In HIV-infected subjects, energy intake, protein breakdown, protein synthesis, and REE were 57% (P < 0.05), 18% (P < 0.05), 22% (P < 0.05) and 14% (P < 0.05) greater than in controls, respectively. REE and protein breakdown were correlated (r = 0.73, P < 0.05). The hormonal profile was normal in HIV-infected subjec...Continue Reading

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Citations

Mar 10, 2005·The American Journal of Clinical Nutrition·Marijka J Batterham
May 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Evelyn ChangAshok Balasubramanyam
Jul 10, 2009·The American Journal of Clinical Nutrition·Pascal CrennJean Claude Melchior
Jun 15, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Roger Kulstad, Dale A Schoeller
Oct 27, 2005·American Journal of Physiology. Endocrinology and Metabolism·Magali Prod'hommeJean Grizard
Nov 18, 2011·The American Journal of Clinical Nutrition·Lisa Kosmiski
Jun 22, 2016·Current Gastroenterology Reports·Robert E CarrollAlan L Buchman
Apr 29, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Pascal CrennLuc Cynober

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