Hyperphagic and anorectic effects of beta-carbolines in a palatable food consumption test: comparisons with triazolam and quazepam

European Journal of Pharmacology
S.J. Cooper

Abstract

The triazolobenzodiazepine triazolam (0.1-1.0 mg/kg i.p.) and quazepam (0.3-30.0 mg/kg i.p.) were administered to non-food-deprived rats which had been partially-satiated on a palatable diet. In a subsequent 30 min feeding test, both compounds produced a significant increase in the level of food consumption. While triazolam had a dose-related effect and produced a 151.5% increase in the level of food intake, quazepam exerted only a partial effect, achieving a 73.9% increase in food intake at 3.0 mg/kg but no additional increase in food intake at higher doses. The two beta-carbolines, ZK 93423 (0.1-3.0 mg/kg i.p.) and ZK 91296 (1.0-30.0 mg/kg i.p.), a full agonist and a partial agonist at benzodiazepine receptors respectively, also produced significant increases in food consumption under the same experimental conditions. ZK 93423 had effects which were similar to those of triazolam, ZK 91296 had effects similar to quazepam. The beta-carboline benzodiazepine inverse agonist FG 7142 (10.0 mg/kg i.p.) had an anorectic effect in non-food-deprived rats given 30 min access to the highly palatable diet. This effect was reversed by the beta-carboline benzodiazepine receptor antagonist ZK 93426 in a dose-dependent manner. These results e...Continue Reading

References

Jan 1, 1985·Neuroscience and Biobehavioral Reviews·S J Cooper, L B Estall
Apr 16, 1985·European Journal of Pharmacology·T KlockgetherK H Sontag
Jan 1, 1985·Psychopharmacology·D N Stephens, W Kehr
Jan 1, 1984·Psychopharmacology·E N PetersenR Schmiechen
Jan 1, 1984·Psychopharmacology·L H JensenR Schmiechen
Dec 15, 1984·Biochemical Pharmacology·W Sieghart, A Schuster
Apr 1, 1980·Journal of Clinical Pharmacology·A KalesP K Schweitzer
Feb 1, 1982·The Journal of Pharmacy and Pharmacology·V H Sethy, D W Harris
Aug 1, 1983·The Journal of Pharmacy and Pharmacology·V H SethyC L Daenzer
Jun 11, 1982·Science·C BraestrupE N Petersen
Jan 1, 1983·Advances in Biochemical Psychopharmacology·C BraestrupT Honoré
Dec 1, 1983·Neuropharmacology·C A BoastK M Bergen

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Citations

Jan 1, 1989·Psychopharmacology·J C Neill, S J Cooper
Jan 1, 1989·European Archives of Psychiatry and Neurological Sciences·F Holsboer
Jul 7, 1988·European Journal of Pharmacology·J C Neill, S J Cooper
Sep 22, 1994·European Journal of Pharmacology·K WegeliusE R Korpi
Jul 1, 1986·Pharmacology, Biochemistry, and Behavior·S J Cooper, R E Yerbury
Mar 1, 1987·Pharmacology, Biochemistry, and Behavior·T C Kirkham, S J Cooper
Dec 1, 1987·Pharmacology, Biochemistry, and Behavior·R E Yerbury, S J Cooper
Jun 1, 1989·Pharmacology, Biochemistry, and Behavior·R E Yerbury, S J Cooper
Jan 1, 1987·Pharmacology & Therapeutics·S E File, S Pellow
Nov 2, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pietro CottoneEric P Zorrilla
Jan 1, 1990·Fundamental & Clinical Pharmacology·M C RybarczykY Cohen

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