Hyperphosphatasemia and concurrent adrenal gland dysfunction in apparently healthy Scottish Terriers

Journal of the American Veterinary Medical Association
Kurt L ZimmermanJoseph H Kinnarney

Abstract

To determine causes of hyperphosphatasemia (high serum alkaline phosphatase [ALP] activity) in apparently healthy Scottish Terriers. Prospective case-controlled study. 34 apparently healthy adult Scottish Terriers (17 with and 17 without hyperphosphatasemia). Serum activities for 3 isoforms (bone, liver, and corticosteroid) of ALP were measured. Concentrations of cortisol, progesterone, 17-hydroxyprogesterone, androstenedione, estradiol, and aldosterone were measured before and after cosyntropin administration (ie, ACTH; 5 microg/kg [2.27 microg/lb], IM). Liver biopsy specimens from 16 dogs (11 with and 5 without hyperphosphatasemia) were evaluated histologically. In dogs with hyperphosphatasemia, the corticosteroid ALP isoform comprised a significantly higher percentage of total ALP activity, compared with the percentage in dogs without hyperphosphatasemia (mean +/- SE, 69 +/- 5.0% and 17 +/- 3.8%, respectively). In 6 dogs with hyperphosphatasemia, but none without, serum cortisol concentrations exceeded reference intervals after ACTH stimulation. Six dogs with and 15 without hyperphosphatasemia had increased concentrations of >or = 1 noncortisol steroid hormone after ACTH stimulation. Serum ALP activity was correlated with co...Continue Reading

Citations

Sep 18, 2014·Journal of the American Veterinary Medical Association·Catherine C CortrightHollis N Erb
Oct 12, 2013·Journal of Veterinary Internal Medicine·E N BehrendJ C Scott-Moncrieff
Feb 20, 2020·Veterinary Surgery : VS·Clément SellierUNKNOWN Hepato-biliary and Pancreatic surgery

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