Hyperplasia of lymphatic vessels in VEGF-C transgenic mice

Science
Michael JeltschKari Alitalo

Abstract

No growth factors specific for the lymphatic vascular system have yet been described. Vascular endothelial growth factor (VEGF) regulates vascular permeability and angiogenesis, but does not promote lymphangiogenesis. Overexpression of VEGF-C, a ligand of the VEGF receptors VEGFR-3 and VEGFR-2, in the skin of transgenic mice resulted in lymphatic, but not vascular, endothelial proliferation and vessel enlargement. Thus, VEGF-C induces selective hyperplasia of the lymphatic vasculature, which is involved in the draining of interstitial fluid and in immune function, inflammation, and tumor metastasis. VEGF-C may play a role in disorders involving the lymphatic system and may be of potential use in therapeutic lymphangiogenesis.

References

Sep 30, 1992·Biochemical and Biophysical Research Communications·B I TermanP Böhlen
Sep 1, 1992·Journal of Veterinary Internal Medicine·T W Fossum, M W Miller
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D MaglioneM G Persico
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R VassarE Fuchs
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·Y MuragakiB R Olsen
May 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D J DumontM L Breitman
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·A KaipainenK Alitalo
Dec 1, 1994·The American Journal of Physiology·R M HaysY Gao
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·B OlofssonU Eriksson
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·J LeeW I Wood
Oct 1, 1996·Cytokine & Growth Factor Reviews·M Klagsbrun, P A D'Amore

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Citations

Jan 14, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M SchneiderJ Wilting
Mar 31, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J WiltingB Christ
Dec 17, 1997·International Journal of Cancer. Journal International Du Cancer·T A OlsonS Ramakrishnan
Mar 17, 2000·International Journal of Cancer. Journal International Du Cancer·J JacquemierD Birnbaum
Oct 19, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Megan E BaldwinMarc G Achen
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Masatsugu UedaMinoru Ueki
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·J LuoM Korc
Jul 31, 2001·International Journal of Cancer. Journal International Du Cancer·Y KitadaiK Chayama
Oct 12, 2001·Microscopy Research and Technique·J Wilting
Oct 12, 2001·Microscopy Research and Technique·J P SleemanP Baumann
Oct 12, 2001·Microscopy Research and Technique·M A Swartz, M Skobe
Oct 12, 2001·Microscopy Research and Technique·M PapoutsiJ Wilting
Oct 12, 2001·Microscopy Research and Technique·T A Partanen, K Paavonen
Oct 12, 2001·Microscopy Research and Technique·M H WitteC L Witte
Feb 17, 2001·The Journal of Pathology·R ClarijsR M de Waal
Dec 18, 2001·The Journal of Pathology·A N WitmerR O Schlingemann
Sep 12, 2002·Prenatal Diagnosis·Imad R MakhoulMoshe Bronshtein
Apr 29, 1998·Pathology Oncology Research : POR·S Paku
Aug 21, 2007·Molecular Diagnosis & Therapy·Kenta Nakamura, Stanley G Rockson
Feb 26, 2005·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·W C Marsch
Feb 8, 2005·World Journal of Surgery·Changyi ChenQizhi Yao
Oct 12, 2012·Seminars in Immunopathology·Subash Babu, Thomas B Nutman
Jul 30, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Helen A Blacker, Sandra Orgeig
Dec 17, 2008·International Journal of Colorectal Disease·Andrew A AlabiJohn Greenman
Oct 3, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Felix BockClaus Cursiefen
Oct 24, 2008·Histochemistry and Cell Biology·Hélène Maby-El Hajjami, Tatiana V Petrova
May 27, 2011·Histochemistry and Cell Biology·Hiroshi ShimodaMarlys H Witte
Oct 5, 2010·Virchows Archiv : an International Journal of Pathology·Elin Hadler-OlsenLars Uhlin-Hansen
Aug 19, 2007·Journal of Cancer Research and Clinical Oncology·Kristen N GanjooCaroline S An
Mar 27, 2010·Surgery Today·Kazuhide KumagaiKennichi Yamagata
Oct 26, 2005·International Journal of Clinical Oncology·Yutaka YonemuraMasahiro Miura
Oct 8, 2005·Angiogenesis·Philippe O Van Trappen, Michael S Pepper
Jun 14, 2006·Cancer Metastasis Reviews·Dave S B HoonKlaus Pantel
Feb 27, 2004·Biochimica Et Biophysica Acta·Yulong HeKari Alitalo
Jan 31, 2004·International Journal of Radiation Oncology, Biology, Physics·Takuma NomiyaShogo Yamada
Jun 15, 2004·Journal of Dermatological Science·Satoshi Hirakawa, Michael Detmar
Feb 26, 2004·Journal of Immunological Methods·Herbert A WeichJonathan Sleeman
Sep 6, 2002·The American Journal of Pathology·Sebastian F SchoppmannDontscho Kerjaschki

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