PMID: 8583291Nov 1, 1995Paper

Hyperplasia of the muscularis propria in response to massive intestinal resection in rat

Journal of Pediatric Gastroenterology and Nutrition
R B ScottD T Tan

Abstract

Adaptation of the muscularis propria to intestinal resection is not well studied. Growing, 150- to 200-g Sprague-Dawley rats were divided into a resected group (R), which had 75% of the jejunoileum removed; a sham-resected group (SR); and a group of untreated controls (C). Food intake and weight gain were documented. Animals were killed on days 0, 10, 20, 30, or 40 (n = 14 animals for each day in each group). Small-intestinal length and jejunal circumference, wet weight/cm, thickness of the muscle layers, muscle morphometry, mg protein, and micrograms DNA per cm of the muscularis propria were measured. R rats had an initially greater food intake than SR or C animals, but the rate of weight gain was not different between groups. There was no significant increase in length of the residual intestine in R animals during the postoperative adaptive period, but circumference was significantly increased in R compared with SR or C animals. Wet weight/cm, mg protein, and micrograms DNA per cm of the muscularis propria were significantly greater in R compared with SR or C animals, but there was no change in thickness of the smooth-muscle layers in R versus SR or C rats. The number of cross-sectioned circular smooth-muscle cells/mm2 and th...Continue Reading

Citations

Jun 13, 2003·Research in Veterinary Science·G BettiniP S Marcato
Jun 19, 2008·Journal of Pediatric Surgery·Colin A MartinBrad W Warner
Apr 30, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Prue M Pereira-FantiniJulie E Bines
Jan 26, 2000·Journal of Pediatric Surgery·C F WeltersE Heineman
May 15, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Andrew W KnottBrad W Warner
Jun 20, 2002·ANZ Journal of Surgery·Carlo F M WeltersErik Heineman
Jul 7, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Valéria Cristina Soares FurtadoAntonio Carlos Iglesias
Feb 2, 2006·Journal of the American Veterinary Medical Association·Stephanie C GormanDaniel L Chan
Jun 20, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·K A SchallT C Grikscheit
Aug 24, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·K LjungmannS Laurberg
May 8, 1999·The American Journal of Physiology·T P O'ConnorJ Diamond
Sep 27, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·K LjungmannS Laurberg
Oct 22, 2009·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Tamás JózsaTamás Roszer
Nov 14, 1998·The American Journal of Physiology·R B ScottJ B Meddings
Dec 17, 2016·The Journal of Surgical Research·Avik KarmakerMarshall Z Schwartz

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