Hyperplastic polyposis coli syndrome and colorectal carcinoma

Endoscopy
C A RubioA Lindblom

Abstract

Patients with hyperplastic polyposis coli syndrome (HPCS) have a propensity to develop colorectal carcinoma (CRC). Details were retrieved from the files of patients attending our hospital between 1988 and 2004 who fulfilled the World Health Organization criteria for HPCS. Over a period of 16 years, 10 cases of HPCS were identified at our hospital (0.625 cases/year or one case every 1.6 years). A mean of 40.3 hyperplastic polyps per patient were found (range 6-159). Other colorectal lesions were found as follows: two patients each had one mixed polyp; there were 15 serrated adenomas in eight patients; and there were 30 tubular, tubulovillous, or villous adenomas in eight patients. Among the 10 patients with HPCS, seven developed a CRC. Of the four villous adenomas, three were associated with a CRC, but only one of the 15 serrated adenomas was associated with a CRC. The pathway of cancer evolution in HPCS patients remains unresolved. Similarly to our results, a review of the literature indicates a high incidence of CRCs in HPCS patients. These patients are at a high risk of developing a CRC and should therefore receive regular colonoscopic surveillance.

Associated Clinical Trials

Mar 26, 2018·Jorge Lopez Vicente

Citations

Nov 26, 2009·Diseases of the Colon and Rectum·Awad M JarrarMatthew F Kalady
Jan 14, 2011·Diseases of the Colon and Rectum·Matthew F KaladyJames M Church
Dec 18, 2010·Familial Cancer·Aedan RobertsJoanne P Young
Jul 14, 2012·The American Journal of Surgical Pathology·Clinton D CrowderWendy L Frankel
Jul 14, 2006·Journal of Clinical Pathology·C A Rubio
Jun 2, 2012·World Journal of Gastroenterology : WJG·Carla GuarinosRodrigo Jover
Apr 9, 2010·Future Oncology·Daniel D BuchananJoanne P Young
Apr 15, 2011·Journal of Biomedicine & Biotechnology·Lucia MiglioreFabio Coppedè
Mar 10, 2010·International Journal of Colorectal Disease·Daniel D BuchananJoanne P Young
Jun 25, 2009·Advances in Anatomic Pathology·Efsevia Vakiani, Rhonda K Yantiss
Sep 27, 2012·European Journal of Gastroenterology & Hepatology·Susana OquiñenaRosario Aznárez
Feb 5, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Carla GuarinosRodrigo Jover
Feb 19, 2013·Cirugía española·Sabela CarballalFrancesc Balaguer
Dec 27, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Seth SweetserFrank A Sinicrope
Mar 20, 2012·Gastrointestinal Endoscopy·Krishna C Vemulapalli, Douglas K Rex
Sep 14, 2010·Best Practice & Research. Clinical Gastroenterology·Mauro Risio
Aug 27, 2010·Gastroentérologie Clinique Et Biologique·J HuppertzS Chaussade
Jul 21, 2010·Gastroenterology·Sakiko HiraokaKazuhide Yamamoto
Jun 1, 2010·Best Practice & Research. Clinical Gastroenterology·Mauro Risio
Oct 2, 2009·Surgical Oncology Clinics of North America·Thomas J McGarrity, Christopher Amos
Jun 11, 2008·Pathology, Research and Practice·Jeremy R Jass
Mar 4, 2008·Gastroenterology Clinics of North America·Susan SummertonMitchell S Cappell
Nov 13, 2007·Gastroenterology Clinics of North America·Jeremy R Jass
Jun 11, 2011·Pathology Research International·Christophe RostyJoanne P Young
Jun 5, 2007·Best Practice & Research. Clinical Gastroenterology·Karsten SchulmannWolff Schmiegel
Oct 15, 2013·American Journal of Medical Genetics. Part a·Emanuela Lucci-CordiscoMaurizio Genuardi
Feb 15, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Daniel L EdelsteinFrancis M Giardiello
May 10, 2015·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Sreejesh SreedharanunniP Gangadharan
May 13, 2015·Nature Reviews. Gastroenterology & Hepatology·Joep E G IJspeertEvelien Dekker
Jun 2, 2015·Archives of Pathology & Laboratory Medicine·Hui-Min YangAntonia R Sepulveda
May 31, 2006·Gastrointestinal Endoscopy·Sebastian DobrowolskiAdam Nałecz
Nov 26, 2015·Gut·J E G IJspeertUNKNOWN Dutch workgroup serrated polyps & polyposis (WASP)
Nov 4, 2010·The American Journal of Gastroenterology·Christopher S HuangMichael J O'Brien
Jun 20, 2012·The American Journal of Gastroenterology·Douglas K RexJames Church
Aug 12, 2014·World Journal of Gastroenterology : WJG·Laura Valle
Feb 19, 2019·Gastroenterology Research and Practice·Gianluca CasseseGiovanni Domenico De Palma

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