PMID: 6408047May 1, 1983Paper

Hyperpnea of exercise at various PIO2 in normal and carotid body-denervated ponies

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
H V ForsterM A Busch

Abstract

We studied the effect of changes in inspired [O2] on partial pressure of CO2 in arterial blood (PaCO2) during treadmill exercise (3 mph, 3% grade) in normal, acute (+2-4 wk), and chronic (+1-2 yr) carotid body-denervated (CBD) ponies. In all studies, PaCO2 decreased (P less than 0.01) from rest during exercise, reaching a nadir usually between 15 and 30 s of exercise. During normoxia [partial pressure of O2 in arterial blood (PaO2) approximately 95 Torr], the PaCO2 nadir was 2.3 +/- 0.6 Torr below resting level in normal ponies, but the nadir was greater (P less than -0.01) in acute (delta = 6.4 +/- 0.8 Torr) and chronic (delta = -4.7 +/- 1.1 Torr) CBD ponies. Hyperoxia (PaO2 approximately 180 Torr) accentuated (P less than 0.01) the hypocapnia only in the normal ponies (delta = -6.3 +/- 1.0 Torr). In contrast, hypoxia (PaO2 48 Torr) attenuated (P less than 0.01) the exercise-induced hypocapnia by 3-5 Torr in all ponies. Usually PaCO2 gradually increased after 30 s of exercise, reaching a stable level 1-3 Torr below rest by about 2 min (P less than 0.05). Tidal volume (VT) increased from rest during the first 15 s of exercise only when there was a large decrease in PaCO2. Recovery of PaCO2 after 30 s of exercise was associated ...Continue Reading

Citations

Jan 1, 1988·Veterinary Research Communications·T Art, P Lekeux
Jan 1, 1985·Journal of Sports Sciences·S K Powers, R E Beadle
Sep 29, 1998·Critical Care Medicine·G J TangY S Lin
Jan 27, 2018·Physiological Genomics·Silvia V CondeMaria P Guarino
Nov 3, 2005·Experimental Physiology·Glen E FosterA William Sheel

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