Hyperpolarised 129 Xe magnetic resonance imaging to monitor treatment response in children with cystic fibrosis

The European Respiratory Journal
Jonathan H RaymentFelix Ratjen

Abstract

Pulmonary magnetic resonance imaging using hyperpolarised 129Xe gas (XeMRI) can quantify ventilation inhomogeneity by measuring the percentage of unventilated lung volume (ventilation defect per cent (VDP)). While previous studies have demonstrated its sensitivity for detecting early cystic fibrosis (CF) lung disease, the utility of XeMRI to monitor response to therapy in CF is unknown. The aim of this study was to assess the ability of XeMRI to capture treatment response in paediatric CF patients undergoing inpatient antibiotic treatment for a pulmonary exacerbation.15 CF patients aged 8-18 years underwent XeMRI, spirometry, plethysmography and multiple-breath nitrogen washout at the beginning and end of inpatient treatment of a pulmonary exacerbation. VDP was calculated from XeMRI images obtained during a static breath hold using semi-automated k-means clustering and linear binning approaches.XeMRI was well tolerated. VDP, lung clearance index and the forced expiratory volume in 1 s all improved with treatment; however, response was not uniform in individual patients. Of all outcome measures, VDP showed the largest relative improvement (-42.1%, 95% CI -52.1--31.9%, p<0.0001).These data support further investigation of XeMRI a...Continue Reading

References

Feb 6, 1998·Journal of Applied Physiology·G K PriskJ B West
Aug 5, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B T SaamM S Conradi
Nov 2, 2004·American Journal of Respiratory and Critical Care Medicine·Paul AuroraUNKNOWN London Cystic Fibrosis Collaboration
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Sep 2, 2005·The European Respiratory Journal·J WangerG Viegi
Nov 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bastiaan DriehuysG Allan Johnson
Feb 17, 2007·American Journal of Respiratory and Critical Care Medicine·Stephanie D DavisMargaret W Leigh
Jun 13, 2009·Respiration; International Review of Thoracic Diseases·Paul D RobinsonPer M Gustafsson
Sep 18, 2009·Seminars in Respiratory and Critical Care Medicine·Nathan C Kraynack, John T McBride
Oct 29, 2010·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·David N Sheppard
Jan 29, 2013·Journal of Magnetic Resonance Imaging : JMRI·John P Mugler, Talissa A Altes
Feb 12, 2013·The European Respiratory Journal·Paul D RobinsonPer M Gustafsson
Feb 26, 2014·American Journal of Respiratory and Critical Care Medicine·Mark O WielpützMarcus A Mall
Dec 23, 2014·Pediatric Pulmonology·Michael S SchechterMichael W Konstan
Sep 12, 2015·American Journal of Respiratory and Critical Care Medicine·Kathryn A RamseyUNKNOWN AREST CF
Jun 16, 2016·PloS One·Renee JensenFelix Ratjen
Jun 19, 2016·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Sanja Stanojevic, Felix Ratjen
Aug 2, 2016·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Robert P ThomenJason C Woods
Sep 13, 2016·Academic Radiology·Mu HeYuh-Chin T Huang
Nov 3, 2016·American Journal of Respiratory and Critical Care Medicine·Carlos E MillaUNKNOWN VX13-809-011 Part B Investigator Group *
Dec 13, 2016·American Journal of Respiratory and Critical Care Medicine·Sanja StanojevicFelix A Ratjen
Jan 31, 2017·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Talissa A AltesJohn P Mugler
Mar 1, 2017·American Journal of Respiratory and Critical Care Medicine·Nikhil KanhereGiles Santyr
Mar 14, 2017·Annals of Internal Medicine·Anne L StephensonChristopher H Goss
Aug 22, 2017·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Marcus SvedbergAnders Lindblad
Oct 7, 2017·The European Respiratory Journal·Esther Oude EngberinkSanja Stanojevic
Aug 9, 2018·Academic Radiology·Giles SantyrMarcus J Couch
Nov 10, 2018·American Journal of Respiratory and Critical Care Medicine·Mirjam StahlMarcus A Mall

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Citations

Nov 9, 2019·The European Respiratory Journal·Rachel L Eddy, Grace Parraga
Nov 26, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marcus J CouchGiles Santyr
Sep 25, 2020·Pediatric Pulmonology·Adrienne P Savant, Susanna A McColley
Dec 4, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Matthew M WillmeringJason C Woods
Sep 15, 2020·Current Opinion in Pulmonary Medicine·Claire NissenbaumJane C Davies
Jul 8, 2020·The European Respiratory Journal·Laurie J SmithJim M Wild
Dec 8, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Faraz AmzajerdianRahim R Rizi
Jun 28, 2020·Pediatric Pulmonology·Jennifer L GoralskiJason C Woods
Jan 18, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Fatmah MallallahDaniel Hind
Feb 27, 2021·Progress in Nuclear Magnetic Resonance Spectroscopy·Helen MarshallJim M Wild
Apr 13, 2021·Expert Review of Respiratory Medicine·Pedro Mondéjar-LópezÒscar Asensio de la Cruz
Oct 9, 2020·American Journal of Respiratory and Critical Care Medicine·Lucy PerremFelix Ratjen
May 27, 2021·Pediatric Radiology·Kushaljit Singh SodhiJuergen Biederer
Dec 9, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Matthew M WillmeringJason C Woods
Jun 10, 2021·The British Journal of Radiology·Neil J StewartJim M Wild
Jun 30, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Philippe ReixUNKNOWN French Cystic Fibrosis Reference Network study group
Aug 21, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Laurie J SmithJim M Wild
Sep 4, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter J NiedbalskiJason C Woods

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