Hyperpolarization-activated inward current in ventricular myocytes from normal and failing human hearts

Circulation
U C HoppeD J Beuckelmann

Abstract

The hyperpolarization-activated inward current (I[f]) was found to be overexpressed in hypertrophied rat ventricular myocytes, indicating that I(f) might favor arrhythmias in hypertrophied or failing ventricular myocardium. In the present study, we evaluated whether I(f) is expressed in human ventricular myocardium, if it may be increased in human heart failure, and if its autonomic modulation may be altered. The whole-cell patch-clamp technique was used to record I(f) in isolated ventricular myocytes from 34 failing (dilated [DCM] or ischemic [ICM] cardiomyopathy) and 13 donor hearts (NF). I(f) was observed in all myocytes showing typical current properties, ie, time and voltage dependence, block by [Cs+]o, permeability for K+ and Na+, and current increase with raising [K+]o. There was a trend toward larger current densities in myopathic (at -130 mV in [K+]o 25 mmol/L; DCM: -1.37 +/- 0.12 pA/pF, n = 50; ICM: -1.39 +/- 0.24 pA/pF, n = 30) than in nonfailing cells (-1.18 +/- 0.21 pA/pF, n = 24), although this difference did not reach statistical significance (P=.23). Boltzmann distributions yielded an activation threshold of -80 mV and half-maximal activation at -110.96 +/- 0.06 mV in myopathic and normal myocytes. Isoproterenol...Continue Reading

References

Sep 1, 1978·The Journal of Physiology·R H Brown, D Noble
Jul 19, 1979·Nature·H F BrownS J Noble
Apr 1, 1979·The Journal of Physiology·D DiFrancesco, P A McNaughton
May 1, 1976·The Journal of General Physiology·R S Kass, R W Tsien
Mar 1, 1992·Pflügers Archiv : European journal of physiology·F Chang, I S Cohen
Dec 1, 1991·Pflügers Archiv : European journal of physiology·A ZazaD DiFrancesco
Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn
Feb 1, 1986·The Journal of Physiology·E Carmeliet, K Mubagwa
May 1, 1988·The Journal of Physiology· Ganitkevich VYaS V Smirnov
Nov 15, 1989·The American Journal of Cardiology·G CasoloC Gori
Jan 7, 1988·The New England Journal of Medicine·D J WilberJ N Ruskin
Apr 1, 1988·American Heart Journal·W B KannelL A Cupples
Jun 1, 1986·The American Journal of Cardiology·W C Roberts
May 1, 1974·The Journal of Clinical Investigation·A C FoxB B Silk
Aug 15, 1974·The New England Journal of Medicine·R R LiberthsonS R Nussenfeld
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
May 1, 1981·The Journal of Physiology·D DiFrancesco
Jul 22, 1982·The New England Journal of Medicine·M R BristowE B Stinson
Dec 1, 1983·The Journal of General Physiology·R Hahin, D T Campbell
Sep 27, 1984·The New England Journal of Medicine·J N CohnT Rector
Sep 1, 1983·The Journal of Physiology·Y E EarmA J Spindler
Jun 1, 1984·Journal of Molecular and Cellular Cardiology·W H NewmanJ G Webb
May 1, 1983·The Journal of Physiology·I S CohenN K Mulrine
Sep 1, 1980·Pflügers Archiv : European journal of physiology·E Carmeliet, J Ramon
May 22, 1980·Nature·A NomaY Watanabe
Jun 1, 1995·The Journal of Physiology·H YuI S Cohen

❮ Previous
Next ❯

Citations

Jun 15, 2007·The Journal of Membrane Biology·C-W SiuR A Li
Jan 6, 2006·Pflügers Archiv : European journal of physiology·María Fernández-VelascoCarmen Delgado
Jul 25, 2009·Pflügers Archiv : European journal of physiology·Natig GassanovUta C Hoppe
Jun 15, 2007·Journal of Biomedical Science·Mario Vassalle
Jan 31, 2007·Medical & Biological Engineering & Computing·Eduardo Marbán, Hee Cheol Cho
Jul 23, 2005·Current Heart Failure Reports·DeeAnn M Rivera, Brian D Lowes
Jan 20, 2004·European Journal of Pharmacology·Yao-Chang ChenCheng-I Lin
Aug 14, 1999·Progress in Biophysics and Molecular Biology·Y Shimoni
Mar 28, 2002·Pharmacology & Therapeutics·A A ArmoundasG F Tomaselli
Jan 15, 2002·Journal of the American College of Cardiology·Yao-Chang ChenCheng-I Lin
Mar 5, 2008·Nature Clinical Practice. Cardiovascular Medicine·Robert D NassFadi G Akar
Mar 11, 2008·Cardiovascular Research·Nadine HardelNikolaj Klöcker
Nov 6, 2010·Cardiovascular Research·Zhiguo WangBaofeng Yang
Jun 2, 2012·Cardiovascular Research·Florian HofmannStefan Herrmann
Apr 30, 2003·Journal of Cardiovascular Pharmacology·Elisabetta CerbaiAlessandro Mugelli
Jul 1, 2010·Journal of Cardiovascular Pharmacology·Zhiguo Wang
Aug 10, 2006·Clinical and Experimental Pharmacology & Physiology·Zhi-Fang YangYuan-Mou Liu
Feb 24, 2009·Canadian Journal of Physiology and Pharmacology·Laura SartianiAlessandro Mugelli
Dec 6, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Tsuyoshi Shiga, Hiroshi Kasanuki
Nov 26, 2010·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Neeraj Parakh, Balram Bhargava
Nov 1, 2007·Future Cardiology·Silvia SuffrediniElisabetta Cerbai
Jun 20, 2013·Heart·Suzanna M C Hardman
Feb 27, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Uta C HoppeErland Erdmann
Feb 22, 2001·Journal of Molecular and Cellular Cardiology·E CerbaiA Mugelli
Oct 27, 2006·American Journal of Physiology. Cell Physiology·Xiao YuZhuan Zhou
Jul 4, 2009·The Journal of Biological Chemistry·Bin Ye, Jeanne M Nerbonne
Feb 10, 2011·Molecular Pharmacology·Qing-Tao MengXiangdong Chen
Jan 13, 2015·International Journal of Molecular Sciences·Stefan HerrmannAndreas Ludwig
Jan 26, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Irina Savelieva, A John Camm
Feb 3, 2016·Current Treatment Options in Cardiovascular Medicine·Takeshi Kitai, W H Wilson Tang
Jan 7, 2015·Journal of Molecular and Cellular Cardiology·Kensuke OshitaMakoto Takano
Aug 21, 2012·Trends in Cardiovascular Medicine·Stefanie FenskeChristian Wahl-Schott
Apr 13, 2010·Biochemical and Biophysical Research Communications·Shuang XiaQiang She
Jul 14, 2009·Journal of Molecular and Cellular Cardiology·Mirko BaruscottiAnnalisa Bucchi
Jun 27, 2009·European Journal of Pharmacology·Eleni BassiakouLila Papadimitriou

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