Hyperpolarization of human mesenchymal stem cells in response to magnetic force

IEEE Transactions on Nanobioscience
Glen R KirkhamSarah Harriet Cartmell

Abstract

Magnetic particle tagging techniques are currently being applied to tissue engineering applications such as controlled differentiation of mesenchymal stem cells (MSC). In order to define key mechanotransducers underpinning these applications, the electrophysiological responses of human MSCs (hMSC) have been investigated. Ferromagnetic microparticles were coated with L-arginyl-glycyl-L-aspartic acid in order to target the application of dynamic force (6 pN) directly to cell surface integrins. Human MSCs demonstrated cell membrane hyperpolarization responses after the application of force, mediated by BK channels and intracellular calcium release.

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Citations

Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Benjamin A EvansAlison E Deatsch
Mar 16, 2018·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Yan LiNing Gu
Aug 5, 2017·Journal of Cellular Physiology·Ekaterina Pchelintseva, Mustafa B A Djamgoz
Nov 23, 2013·Integrative Biology : Quantitative Biosciences From Nano to Macro·Devrim Kilinc, Gil U Lee
Sep 25, 2019·Stem Cell Research & Therapy·Kyong-Su ParkJan Lötvall
Apr 13, 2021·Journal of Biomaterials Applications·Valerii B OrelValerii E Orel

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