Hyperpolarized 129 Xe gas transfer MRI: the transition from 1.5T to 3T

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Ziyi WangBastiaan Driehuys

Abstract

Hyperpolarized 129 Xe MRI depicting 3D ventilation, interstitial barrier uptake, and transfer to red blood cells (RBCs) has emerged as a powerful new means of detecting pulmonary disease. However, given the challenging susceptibility environment of the lung, such gas transfer imaging has, thus far, only been implemented at 1.5T. Here, we seek to demonstrate the feasibility of Dixon-based 129 Xe gas transfer MRI at 3T. Seven healthy subjects and six patients with pulmonary disorders were recruited to characterize 129 Xe spectral structure, optimize acquisition parameters, and acquire representative images. Imaging used randomized, gradient-spoiled 3D-radial encoding of 1000 gas (0.5° flip) and dissolved (20° flip) views, reconstructed into 3-mm isotropic voxels. The center of k-space was sampled when barrier and RBC compartments were 90° out of phase (TE90 ). A single dissolved phase spectrum was appended to the sequence to measure the global RBC-barrier ratio for Dixon-based decomposition. A 0.69 ms sinc was found to generate minimal off-resonance gas-phase excitation (3.0 ± 0.3% of the dissolved-phase), yielding a TE90  = 0.47 ± 0.02 ms. The RBC and barrier resonance frequencies were shifted by 217.6 ± 0.6 ppm and 197.8 ± 0.2 ...Continue Reading

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Citations

Mar 14, 2020·Journal of Magnetic Resonance Imaging : JMRI·Andreas Voskrebenzev, Jens Vogel-Claussen
Oct 18, 2019·The European Respiratory Journal·Ziyi WangSudarshan Rajagopal
Dec 4, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Matthew M WillmeringJason C Woods
Jun 20, 2020·Journal of Applied Physiology·Peter J NiedbalskiZackary I Cleveland
Apr 1, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Agilo L KernJens Vogel-Claussen
Dec 1, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Guilhem J CollierJim M Wild
Feb 26, 2019·Journal of Thoracic Imaging·Joseph G MammarappallilBastiaan Driehuys
Mar 6, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Matthew M WillmeringJason C Woods
Feb 27, 2021·Progress in Nuclear Magnetic Resonance Spectroscopy·Helen MarshallJim M Wild
Aug 6, 2021·Journal of Magnetic Resonance Imaging : JMRI·Laura C SaundersJim M Wild
Sep 4, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter J NiedbalskiJason C Woods
Oct 14, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter J NiedbalskiBastiaan Driehuys

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