Hyperpolarized magnetic resonance spectroscopy for assessing tumor hypoxia

Acta Oncologica
Ane B IversenM R Horsman

Abstract

Hypoxic tumor cells are radioresistant, therefore, identification of hypoxia is crucial. Hyperpolarized magnetic resonance spectroscopy (HPMRS) allows real time measurements of the conversion of pyruvate to lactate, the final step of anaerobic energy production, and may thus allow non-invasive identification of hypoxia or treatment-induced changes in oxygenation. The aim of the study was to investigate the usefulness of HPMRS as a means to assess tumor hypoxia and its dynamics during intervention. C3H mammary carcinomas grown in CDF1 mice were used. To manipulate with tumor oxygenation, non-anaesthetized mice were gassed with air, 10% or 100% oxygen prior to administration of hyperpolarized [1-¹³C]pyruvate and HPMRS analysis. A direct assessment of tumor oxygen partial pressure (pO2) distributions were made using the Eppendorf oxygen electrode in a separate, but similarly treated, group of mice. Even though breathing 100% oxygen improved tumor oxygenation as evidenced by pO2 measurements, the mean (with 1 S.E.) [1-¹³C]lactate/[1-¹³C]pyruvate ratio was unaffected by this intervention, being 34 (30-37) in mice breathing air and 37 (33-42) in mice breathing 100% oxygen. In contrast, and in accordance with pO2 measurements, a signi...Continue Reading

References

Nov 1, 1989·International Journal of Radiation Biology·J Overgaard
Jan 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M HöckelP Vaupel
Oct 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M NordsmarkJ Overgaard
Oct 23, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A W FylesR P Hill
Aug 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jan H Ardenkjaer-LarsenKlaes Golman
Oct 25, 2003·International Journal of Radiation Oncology, Biology, Physics·Michael R Horsman, Rumi Murata
Oct 14, 2004·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Daniel ZipsMichael Baumann
Mar 10, 2006·International Journal of Radiation Biology·Slavka LukacovaMichael R Horsman
Mar 21, 2008·International Journal of Cancer. Journal International Du Cancer·Morten BuskJens Overgaard
Aug 7, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Morten BuskJens Overgaard
Oct 19, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Keita SaitoMurali C Krishna
Jun 14, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shingo MatsumotoMurali C Krishna
Nov 15, 2012·Nature Reviews. Clinical Oncology·Michael R HorsmanJens Overgaard
Aug 16, 2013·Science Translational Medicine·Sarah J NelsonJonathan A Murray

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Citations

Nov 18, 2017·Acta Oncologica·Cai GrauJens Overgaard
Mar 10, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Haiyun QiChristoffer Laustsen
Aug 22, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Sonja StiebOliver Riesterer

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