PMID: 6967458Jan 1, 1980Paper

Hyperproduction of IgE and T-cell dysfunction in Hodgkin's disease

International Archives of Allergy and Applied Immunology
S RomagnaniM Ricci

Abstract

Serum IgE levels were evaluated in 119 untreated and 112 treated patients with Hodgkin's disease (HD). 38 of the nonatopic untreated patients showed significantly increased (> 300 IU/ml) IgE concentrations. No relationship could be found between increased IgE levels and depressed lymphocyte response to phytohemagglutinin (PHA) or the imbalance of TM and TG lymphocyte subsets. On the other hand, the mean level of suppressor activity elicitable from cells of untreated HD patients by concanavalin A preincubation did not differ significantly from that of healthy control subjects. In contrast, in treated patients, where there was a significant reduction in the number of circulating T lymphocytes, a further depression of the lymphocyte response to PHA, a more marked disproportion of TM and TG cell subsets and a noticeable fall in IgE concentration was found. These data suggest that increased IgE concentrations seen in untreated patients with HD are unrelated to the T-cell defects. They also suggest that hyperproduction of IgE is probably not invariably a consequence of a suppressor cell deficiency.

Citations

Jan 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E MaggiM Ricci
Mar 1, 1993·Leukemia & Lymphoma·M Samoszuk, E Ramzi
May 21, 2010·Pediatric Blood & Cancer·Manas KalraSatya Prakash Yadav
Mar 1, 1991·Journal of Clinical Immunology·A CarrR Penny
May 31, 2002·Blood·Brian F Skinnider, Tak W Mak

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