Hyperprogressive disease and its clinical impact in patients with recurrent and/or metastatic head and neck squamous cell carcinoma treated with immune-checkpoint inhibitors: Korean cancer study group HN 18-12.

Journal of Cancer Research and Clinical Oncology
Ji Hyun ParkBhumsuk Keam

Abstract

Although immune-checkpoint inhibitors (ICIs) have emerged as therapeutic options for recurrent and/or metastatic head and neck squamous cell carcinoma (R/M-HNSCC), concerns have been raised on exceptional acceleration of tumor growth during treatment with ICIs, a condition described as hyperprogressive disease (HPD). This study examined the incidence, potential predictors, and clinical impact of HPD in R/M-HNSCC. We retrospectively collected data of patients with R/M-HNSCC treated with ICIs between January 2013 and June 2018 from 11 medical centers in Korea. HPD was defined as tumor growth kinetics ratio (TGKr) > 2, which was calculated by comparing TGK on ICIs with that before treatment with ICIs. Of 125 patients, 68 (54.4%) obtained progressive disease as their best responses (progressors). HPD was identified in 18 (26.5% of progressors, 14.4% of total) patients. Relatively younger age, primary tumor of oral cavity, and previous locoregional irradiation were significant predictors of HPD according to multivariable analysis (p = 0.040, 0.027, and 0.015, respectively). Compared to patients without HPD, patients with HPD had significantly shorter median progression-free survival (PFS) (1.2 vs. 3.4 months, p < 0.001) and overall ...Continue Reading

References

Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Mar 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J Simon W StewartEverett E Vokes
Oct 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Soroosh RadfarHung T Khong
Mar 3, 2011·Nature Reviews. Clinical Oncology·Laurence ZitvogelGuido Kroemer
Jul 17, 2015·Anti-cancer Agents in Medicinal Chemistry·Alberta Lucchese
Oct 11, 2016·The New England Journal of Medicine·Robert L FerrisMaura L Gillison
Nov 9, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stéphane ChampiatCharles Ferté
Mar 30, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shumei KatoRazelle Kurzrock
Apr 19, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E Saâda-BouzidC Le Tourneau
Jul 10, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Amaury DasteAlain Ravaud
Nov 5, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Song Ee ParkJong-Mu Sun
Nov 11, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sandrine AspeslaghSophie Postel-Vinay
Dec 2, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Gustavo SchvartsmanWilliam N William
Apr 13, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C G KimH R Kim
Apr 16, 2019·Head & Neck·Jamie R OliverBabak Givi
Jun 14, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Youjin KimKeunchil Park
Oct 2, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Khalil SalehCaroline Even
Nov 24, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ignacio MatosElena Garralda
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C G KimH R Kim

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Jun 17, 2021·World Journal of Clinical Oncology·Davide IppolitoSandro Sironi

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