PMID: 9448878Aug 1, 1997Paper

Hyperprolactinaemia in males: a heterogeneous disorder

Australian and New Zealand Journal of Medicine
J P Walsh, P T Pullan

Abstract

The literature suggests that men with prolactinomas typically present with pressure effects of large pituitary tumours and/or the clinical features of hypogonadism. A definitive study of the clinical features of hyperprolactinaemia in males is, however, lacking To identity the clinical, biochemical and radiological features of hyperprolactinaemia in males. Retrospective review of the case notes of 53 adult males with prolactinoma or idiopathic hyperprolactinaemia diagnosed 1980-1995. The mean age of the patients was 41 years (range 19-75). The presenting symptom was endocrine in nature in 57% of patients (loss of libido/potency 47%, gynaecomastia 6%, galactorrhoea 2%, sparse beard growth 2%), pressure effects of pituitary tumour in 28% (headache 13%, visual loss 13%, diplopia 2%), while 15% of patients presented incidentally. On physical examination, galactorrhoea was present in 8% of patients, gynaecomastia in 23% and abnormally sparse body hair in 21%. Testicular volume was normal (> or = 15 mL) in all but two patients, both of whom had evidence of delayed pubertal development. Visual loss was present in 17% of patients. Serum prolactin ranged from 800 to 1.7 million mU/L (median 20,000 mU/L, reference range < 500), and serum...Continue Reading

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Citations

May 13, 2005·World Journal of Urology·Tillmann H C KrügerManfred Schedlowski
Dec 28, 2005·Pituitary·Arijit ChattopadhyayShariq R Masoodi
Jun 29, 2002·Life Sciences·Anna Maria Meaney, Veronica O'Keane
May 27, 2003·Surgical Neurology·Hiroshi NishiokaKiyohiro Akada
Feb 12, 2002·Neuroscience and Biobehavioral Reviews·Tillmann H C KrügerMichael S Exton
Jun 30, 2005·Journal of Psychiatric Practice·Uriel Halbreich, Linda S Kahn
May 6, 2005·Treatments in Endocrinology·Johan Verhelst, Roger Abs
Jul 1, 2011·The Australian and New Zealand Journal of Psychiatry·Warrick J Inder, David Castle
Sep 28, 2012·Journal of Endocrinological Investigation·M GaldieroA Colao
Dec 1, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Annamaria Colao
Feb 1, 2012·Clinical Endocrinology·Pedro IglesiasJuan J Díez
Jul 26, 2012·Systematic Reviews·Amy T WangMohammad Hassan Murad
Mar 29, 2003·ANZ Journal of Surgery·Ian R Daniels, Graham T Layer
Aug 26, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Annamaria ColaoGaetano Lombardi
Mar 28, 2018·Experimental Dermatology·Ewan A LanganRalf Paus
Jan 9, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·M SteinhoffC C Zouboulis
Sep 22, 2000·The Journal of Clinical Endocrinology and Metabolism·J J PinzoneA Klibanski
May 18, 2006·Endocrine Reviews·Mary P GillamAnnamaria Colao
Feb 6, 2004·Arquivos de neuro-psiquiatria·Gisele Rieffel BraucksAlice Helena Dutra Violante
Nov 18, 2019·Current Urology Reports·Shiri LevySudhaker D Rao
Dec 6, 2019·Pituitary·Hadar Duskin-Bitan, Ilan Shimon
Sep 1, 2012·Journal of Endocrinological Investigation·M GaldieroA Colao

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