Hyperreflective Foci Number Correlates with Choroidal Neovascularization Activity in Angioid Streaks

Investigative Ophthalmology & Visual Science
Maurizio Battaglia ParodiFrancesco Bandello

Abstract

To assess the changes in hyperreflective foci (HF) by means of spectral-domain optical coherence tomography (SD-OCT) in patients undergoing anti-VEGF treatment for subfoveal choroidal neovascularization (CNV) secondary to angioid streaks (AS). Fifteen eyes with diagnosis of AS-related CNV (8 males) and 15 control eyes with uncomplicated AS were consecutively recruited. Patients and controls underwent complete ophthalmologic examination and SD-OCT. Patients were subjected to a pro re nata treatment regimen, including monthly examinations and intravitreal aflibercept injection in case of fluid detection on SD-OCT. HF were measured on horizontal scans of the six-line radial SD-OCT, in the fovea and parafovea and the subdivided as retinal or choroidal. Specifically, HF were analyzed at the following time points: baseline, dry on SD-OCT, 1 month before its reactivation, and the time of CNV reactivation. HF numbers resulted higher in all CNV phases with respect to controls, except during inactive phase. Moreover, foveal and parafoveal HF were found significantly increased in active, prereactive, and reactive phases when compared with inactive phase (P < 0.05). A similar trend was detected for choroidal HF. Interestingly, a subanalysi...Continue Reading

References

Mar 1, 1982·Survey of Ophthalmology·J G Clarkson, R D Altman
Oct 15, 1993·American Journal of Ophthalmology·J I LimS B Bressler
May 5, 2009·Ophthalmology·Matthias BolzUNKNOWN Diabetic Retinopathy Research Group Vienna
Aug 20, 2010·American Journal of Ophthalmology·Gerard MimounEric H Souied
Sep 26, 2012·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Gabriel CoscasEric Souied
Jan 29, 2013·Ophthalmology·Joseph G ChristenburyUNKNOWN Age-related Eye Disease Study 2 Ancillary Spectral Domain Optical Coherence Tomography Study Group
Nov 12, 2013·American Journal of Ophthalmology·Maurizio Battaglia ParodiFrancesco Bandello
Mar 1, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Joon-Won KangHyung Chan Kim
Aug 30, 2014·Retina·Umberto De BenedettoFrancesco Bandello
Nov 2, 2016·Investigative Ophthalmology & Visual Science·D Scott McLeodGerard A Lutty
Feb 25, 2017·European Journal of Ophthalmology·Maurizio Battaglia ParodiFrancesco Bandello
Oct 25, 2017·Retina·Maurizio Battaglia ParodiPierluigi Iacono

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Citations

Aug 9, 2019·Ocular Immunology and Inflammation·Maria Vittoria CicinelliGiulio Maria Modorati
Jul 7, 2019·Eye·Francesco RomanoMaurizio Battaglia Parodi
Dec 5, 2019·Retina·Francesco RomanoMaurizio Battaglia Parodi
Sep 8, 2019·Journal of Clinical Medicine·Alessandro ArrigoMaurizio Battaglia Parodi
Dec 14, 2019·Translational Vision Science & Technology·Alessandro ArrigoMaurizio Battaglia Parodi
May 12, 2021·Eye·Alessandro MarcheseMaurizio Battaglia Parodi

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