Hypersensitivity of lurcher mutant mice to the depressing effects of lipopolysaccharide and interleukin-1 on behaviour

Neuroreport
R M BluthéRobert Dantzer

Abstract

Lurcher mutant mice are characterized by a fast and almost total loss of olivocerebellar neurones during the first postnatal month, associated with a chronic inflammatory state. To test their brain sensitivity to proinflammatory cytokines, we assessed the behavioural responses of adult male Lurcher and wild type to an i.p. or i.c.v. injection of rat recombinant IL-1 beta, and lipopolysaccharide (LPS). IL-1 beta (15 micrograms kg-1, i.p. or 1 ng i.c.v.) decreased social exploration measured 2, 4 and 6 h later, and this decrease was significantly more pronounced in Lurcher than in wild type mice. LPS (60 micrograms kg-1, i.p. or 5 ng i.c.v.) decreased social exploration measured 2 and 4 h later, and this effect was also significantly more marked in Lurcher than in wild type mice. These results suggest that the chronic inflammatory state which characterizes Lurcher mice renders these animals more sensitive to the effects of cytokines such as IL-1 beta and LPS. This difference may be due to the higher reactivity of brain macrophages and glial cells to LPS and IL-1 in Lurcher mice than in wild type.

References

Oct 11, 1979·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K W Caddy, T J Biscoe

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Citations

Nov 28, 2007·Psychosomatic Medicine·Joel E Dimsdale, Robert Dantzer
Sep 6, 2011·The Psychiatric Clinics of North America·Michael R Irwin
Jan 18, 2006·Brain Research·Michael W VogelJean Mariani
Dec 22, 1999·Brain, Behavior, and Immunity· BluthF Homo-Delarche

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